文献类型：期刊文献

中文题名：喷雾干燥法制备丹参酮前体脂质体的研究

英文题名：Study on the preparation of tanshinone proliposomes by spray drying method

作者：储茂泉[1];古宏晨[1];刘国杰[1]

机构：[1]华东理工大学化学与制药学院,上海200237

年份：2002

卷号：37

期号：1

起止页码：32

中文期刊名：中国药学杂志

外文期刊名：Chinese Pharmaceutical Journal

收录：CSTPCD;;EI(收录号：2002176929104);Scopus;北大核心:【北大核心2000】；CSCD:【CSCD2011_2012】；PubMed;

语种：中文

中文关键词：丹参酮;喷雾干燥;前体脂质体;生物利用度;稳定性

外文关键词：Hydration;Morphology;Thin films

摘要：目的　提高丹参酮 (tanshinone)的生物利用度及其脂质体的稳定性。方法　先采用薄膜法将丹参酮制备成脂质体混悬液 ,然后采用喷雾干燥法将其制备成前体脂质体。结果　丹参酮前体脂质体为干燥的球形粒子 ,粒度约 5 μm ;前体脂质体水合而重建的脂质体的粒度分布与喷雾干燥前的脂质体无明显差别 ,脂质体呈球形或椭球形 ,无明显团聚现象 ;脂质体中的丹参酮和大豆磷脂在喷雾干燥过程中均较稳定。结论　喷雾干燥法制备丹参酮前体脂质体是可行的。
OBJECTIVE: To enhance the bioavailability of tanshinone and the stability of tanshinone liposomes. METHODS: The tanshinone liposomes dispersion was prepared by thin film hydration method. Then the powder of proliposomes was achieved by spray drying process. RESULTS: The tanshinone proliposomes were of dried particles with spherieal shape, and their size were about 5 μm. The vesicle size distribution of tanshinone proliposomes was not significantly changed compared with that before spray drying. The morphology of the vesicles were spherical or ellipsoidal, and no congregated vesicles were found. Both tanshinone and the soybean lecithin in liposome were stable during the spray drying process. CONCLUSION: The preparation of tanshinone proliposome by spray drying method was practical.