文献类型：期刊文献

英文题名：Promoting the Near-Infrared-II Fluorescence of Diketopyrrolopyrrole-Based Dye for In Vivo Imaging via Donor Engineering

作者：Yuan, Tao[1,2];Xia, Qiming[3,4];Wang, Zhiqiang[5,6,7];Li, Xinsheng[1,2];Lin, Hui[4];Mei, Ju[1];Qian, Jun[2,3,4];Hua, Jianli[1,2]

机构：[1]East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Frontiers Sci Ctr Materiobiol & Dynam Chem, Sch Chem & Mol Engn,Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Frontiers Sci Ctr Materiobiol & Dynam Chem, Sch Chem & Mol Engn,Joint Int Res Lab Precis Chem, Shanghai 200237, Peoples R China;[3]Zhejiang Univ, Coll Opt Sci & Engn, Int Res Ctr Adv Photon, Ctr Opt & Electromagnet Res,State Key Lab Extreme, Hangzhou 310058, Peoples R China;[4]Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept Gen Surg, Hangzhou 310016, Peoples R China;[5]East China Univ Sci & Technol, Sch Chem & Mol Engn, Ctr Computat Chem, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[6]East China Univ Sci, Ctr Computat Chem, Sch Chem & Mol Engn, Joint Int Res Lab Precis Chem & Mol Engn, Shanghai 200237, Peoples R China;[7]East China Univ Sci & Technol, Res Inst Ind Catalysis, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China

年份：2024

卷号：16

期号：4

起止页码：4478

外文期刊名：ACS APPLIED MATERIALS & INTERFACES

收录：;EI(收录号：20240515464048);WOS:【SCI-EXPANDED(收录号:WOS:001155537400001)】；

基金：For financial support of this research, the authors thank the projects supported by the National Natural Science Foundation of China (21788102, 22271093, and 21971064), the Shanghai Municipal Science and Technology Major Project (grant no. 2018SHZDZX03), the Fundamental Research Funds for the Central Universities (222201717003 and 50321101918001), and the Programme of Introducing Talents of Discipline to Universities (B16017).

语种：英文

外文关键词：NIR-II bioimaging; diketopyrrolopyrrole; small-moleculedyes; donor engineering; nanoparticles

摘要：Small-molecule dyes for fluorescence imaging in the second near-infrared region (NIR-II, 900-1880 nm) hold great promise in clinical applications. Constructing donor-acceptor-donor (D-A-D) architectures has been recognized to be a feasible strategy to achieve NIR-II fluorescence. However, the development of NIR-II dyes via such a scheme is hampered by the lack of high-performance electron acceptors and donors. Diketopyrrolopyrrole (DPP), as a classic organic optoelectronic material, enjoys strong light absorption, high fluorescence quantum yield (QY), and facile derivatization. Nevertheless, its application in the NIR-II imaging field has been hindered by its limited electron-withdrawing ability and the aggregation-caused quenching (ACQ) effect resulting from the planar structure of DPP. Herein, with DPP as an electron acceptor and through donor engineering, we have successfully designed and synthesized a DPP-based dye named T-27, in which the strong D-A interaction confers excellent NIR absorption and high-brightness NIR-II fluorescence tail emission. By strategically introducing long alkyl chains on the donor unit to increase intermolecular spacing and reduce the influence of solvent molecules, T-27 exhibits an improved anti-ACQ effect in aqueous solutions. After being encapsulated into DSPE-PEG(2000), T-27 nanoparticles (NPs) show a relative NIR-II fluorescence QY of 3.4% in water, representing the highest value among the DPP-based NIR-II dyes reported to date. The outstanding photophysical properties of T-27 NPs enable multimode NIR-IIa bioimaging under 808 nm excitation. As such, the T-27 NPs can distinguish mouse femoral vein and artery and achieve cerebral vascular microscopic imaging with a penetrating depth of 800 mu m, demonstrating the capability for high-resolution deep-tissue imaging. This work holds significant potential in the field of bioimaging and provides a new strategy for developing bright NIR-II dyes.