文献类型：期刊文献

英文题名：Functionalized mesoporous bioactive glass scaffolds for enhanced bone tissue regeneration

作者：Zhang, Xingdi[1];Zeng, Deliang[2];Li, Nan[1];Wen, Jin[2];Jiang, Xinquan[2];Liu, Changsheng[3];Li, Yongsheng[1]

机构：[1]E China Univ Sci & Technol, Sch Mat Sci & Engn, Lab Low Dimens Mat Chem, Key Lab Ultrafine Mat,Minist Educ, Shanghai 200237, Peoples R China;[2]Shanghai Jiao Tong Univ, Sch Med, Peoples Hosp 9, Dept Prosthodont, Shanghai 200011, Peoples R China;[3]E China Univ Sci & Technol, Minist Educ, Engn Res Ctr Biomed Mat, Shanghai 200237, Peoples R China

年份：2016

卷号：6

外文期刊名：SCIENTIFIC REPORTS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000368161100001)】；

基金：This work was financially supported by the 973 Program (Grant No. 2012CB933600), the National Natural Science Foundation of China (Grant No. 81300853, 51132009, 51202068, 5141101086, 81225006), the Shu Guang project (Grant No. 11SG30) and the Fundamental Research Funds for the Central Universities.

语种：英文

摘要：Mesoporous bioactive glass (MBG), which possesses excellent bioactivity, biocompatibility and osteoconductivity, has played an important role in bone tissue regeneration. However, it is difficult to prepare MBG scaffolds with high compressive strength for applications in bone regeneration; this difficulty has greatly hindered its development and use. To solve this problem, a simple powder processing technique has been successfully developed to fabricate a novel type of MBG scaffold (MBGS). Furthermore, amino or carboxylic groups could be successfully grafted onto MBGSs (denoted as N-MBGS and C-MBGS, respectively) through a post-grafting process. It was revealed that both MBGS and the functionalized MBGSs could significantly promote the proliferation and osteogenic differentiation of bMSCs. Due to its positively charged surface, N-MBGS presented the highest in vitro osteogenic capability of the three samples. Moreover, in vivo testing results demonstrated that N-MBGS could promote higher levels of bone regeneration compared with MBGS and C-MBGS. In addition to its surface characteristics, it is believed that the decreased degradation rate of N-MBGS plays a vital role in promoting bone regeneration. These findings indicate that MBGSs are promising materials with potential practical applications in bone regeneration, which can be successfully fabricated by combining a powder processing technique and post-grafting process.