文献类型：期刊文献

英文题名：PyfSeTs as a novel and photosensitive reagent for green light-induced arene C-H selenenylation: a versatile strategy for the synthesis of aryl selenides

作者：Shi, Haoliang[1,2];Qu, Huorong[1,2];Wang, Xinyan[1,2];Wei, Jinlian[1,2];Wu, Shanchao[3];Zhang, Yongqiang[1,2]

机构：[1]East China Univ Sci & Technol, Shanghai Frontiers Sci Ctr Optogenet Tech Cell Met, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China;[3]Naval Med Univ, Mil Med Univ 2, Sch Pharm, Ctr Basic Res & Innovat Med & Pharm,MOE, Shanghai 200433, Peoples R China

年份：2026

外文期刊名：ORGANIC & BIOMOLECULAR CHEMISTRY

收录：;EI(收录号：20261320334633);WOS:【SCI-EXPANDED(收录号:WOS:001721155500001)】；

基金：The financial support from the Program of the National Natural Science Foundation of China (22471072, Y. Z.) and the Natural Science Foundation of Shanghai Municipality (23ZR1417200, Y. Z.) is gratefully acknowledged.

语种：英文

外文关键词：Aromatic hydrocarbons - Drug discovery - Drug products - Molecular oxygen - Reagents - Redox reactions - Selenium compounds

摘要：Herein, we report the discovery of a novel and photosensitive seleno donor reagent, Se-(perfluoropyridin-4-yl) 4-methylbenzenesulfonoselenoate (PyfSeTs), for green light-induced site selective C-H selenation of a variety of arenes using molecular oxygen as the oxidant. In particular, the perfluoropyridylselenyl group of the product could be activated using a redox process, enabling the generation of active selenium species for various transformations and offering a versatile platform for C-Se bond construction and arylselenide synthesis. The preparative power of the transformations has been further highlighted in the synthesis of selenoflavones and their analogues, which leads to the discovery of two attractive lead compounds for anticancer drug discovery.