文献类型：期刊文献

英文题名：One-Step Preparation of Phenyl Boron-Modified Magnetic Mesoporous Silica for Selective Enrichment of cis-Diol-Containing Substances

作者：Fu, Hua[1,2];Hu, Jing[1];Zhang, Min[3];Wang, Yuerong[1];Zhang, Hongyang[1];Hu, Ping[1]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China;[2]Qinghai Univ, Sch Chem Engn, Xining 810016, Qinghai, Peoples R China;[3]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China

年份：2018

卷号：23

期号：3

外文期刊名：MOLECULES

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000428514100094)】；

基金：This research was supported financially by the National Natural Science Foundation of China (Nos. 81273481 and 81202493). This is an open project of the State Key Laboratory of Quality Research in Chinese Medicine (Macau University of Science and Technology, MUST-SKL-2016-06) funded by the Macao Science and Technology Development Fund, Macau special administrative region.

语种：英文

外文关键词：magnetic solid-phase extraction; one-step preparation; phenylboronic acid; cis-diol-containing substance; selective enrichment

摘要：For enrichment and separation of cis-diol-containing compounds from biomatrix, a new type of magnetic nanoparticles named MS-48-PBSC, which was facilely prepared in a one-step heterogeneous reaction. The morphology results demonstrated that the MS-48-PBSC was a spherical nanomaterial containing a core of silica-coated magnetic particle with a diameter of about 200 nm, and a cover layer of mesoporous silica with a thickness of approximate 50 nm. The characterization results showed that MS-48-PBSC presented a pore size of 4.2 nm, a surface area of 548 m(2).g(-1), and a pore volume of 0.30 cm(3).g(-1). The MS-48-PBSC also exhibited magnetism of 42 emu.g(-1) that contributed to the easy separation of magnetic nanomaterial within 30 s from the matrix with the aid of the external magnetic field. In addition, the MS-48-PBSC exhibited high adsorption capacity for adenosine, xanthosine, uridine, sialic acid, and teicoplanin with 0.60, 0.51, 0.42, 0.75, and 1.26 mg/g, respectively, and showed a high selectivity for the cis-diol structure compounds, relative to interferences of bovine serum albumin, guanine, uric acid, and xanthine. The recoveries of adenosine, xanthosine, uridine, sialic acid, and teicoplanin were 71.8-114.1% with relative standard deviation (RSD) <= 8.6%, and the enrichment factors of them were 8-11. MS-48-PBSC exhibited quick separation capability from matrix, high adsorption capacity and size exclusion for bovine serum albumin, which could meet the requirements of separation and enrichment for substances with a cis-diol structure.