文献类型：期刊文献

英文题名：Dipeptide L-Valine-Tryptophan decorated graphene oxide membrane with retarded transportation in chiral separation

作者：Wang, Fang[1,2];Fu, Xiaolei[1,2];Zhang, Rutong[1,2];Lei, Rong[1,2];Chen, Qibin[1,2]

机构：[1]East China Univ Sci & Technol, State Key Lab Chem Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China

年份：2025

卷号：374

外文期刊名：SEPARATION AND PURIFICATION TECHNOLOGY

收录：;EI(收录号：20252118488834);WOS:【SCI-EXPANDED(收录号:WOS:001500431900011)】；

基金：This work is supported by the Fundamental Research Funds for the Central Universities (2022ZFJH004) and the 111 Project of Ministry of Education of China.

语种：英文

外文关键词：Graphene oxide; Retarded transport mechanism; Membranes; Enantioselectivity

摘要：The high-efficiency chiral separation of racemic mixtures remains a huge challenge due to their same physicochemical properties in achiral environments. The chiral selectors immobilized into membranes that have been widely applied in enantioseparation can effectively differentiate enantiomers by means of the intermolecular interaction, including enantioselective and/or non-enantioselective attraction/repulsion. In this work, an efficacious chiral separation membrane was created via selecting dipeptide L-Valine-Tryptophan as a chiral recognition site to modify graphene oxide (GO) nanosheets; FT-IR, XPS, TEM, AFM, SEM, XRD were used to characterize the structure of GOs, dipeptide modified GOs, and their corresponding membranes; the enantioseparation performance of dipeptide modified GO membranes toward D- and L-phenylalanine (D- and L-Phe) was mainly detected, while other three enantiomers, i.e., D- and L-Tryptophan (D- and L-Trp), D- and L-Tyrosine (Dand L-Tyr), and D- and L- Aspartate (D- and L-Asp), were selected as controls. Results show that such dipeptide modified GO membranes possess an optimal separation factor of 2.38 and a 1-3 orders of magnitude higher flux relative to conventional chiral separation membranes and follow the retarded transport mechanism. Our findings suggest that dipeptide modified GO membranes have a promising prospect for broad applications in achieving continuous operations and large-scale productions of pure enantiomers; in particular, the non-enantioselective interactions triggered on in a properly confined space, as an alternative to the enlarged enantioselective interactions, can be effectively used to improve the enantioselectivity during the chiral separation.