文献类型：期刊文献

中文题名：A dual-modality hydrogen sulfide-specific probe integrating chemiluminescence with NIR fluorescence for targeted cancer imaging

作者：Xuemei Dong[1];Lixin Sun[1];Ziwen Zhang[2];Tianli Zhu[1];Jie Sun[1];Jinzhu Gao[1];Chengjun Dong[1];Rongchen Wang[1];Xianfeng Gu[2];Chunchang Zhao[1]

机构：[1]Key Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research Center,Institute of Fine Chemicals,School of Chemistry and Molecular Engineering,East China University of Science and Technology,Shanghai 200237,China;[2]Department of Medicinal Chemistry,School of Pharmacy,Fudan University,Shanghai 201203,China

年份：2023

卷号：66

期号：6

起止页码：1869

中文期刊名：Science China Chemistry

外文期刊名：中国科学（化学英文版）

收录：CSTPCD;;Scopus;CSCD:【CSCD2023_2024】；PubMed;

基金：supported by the National Natural Science Foundation of China(22077030,22271092,21977018,82173657);the China Postdoctoral Science Foundation(2021M701196)。

语种：英文

中文关键词：chemiluminescence;fluorescence;BODIPY;dual-modal imaging;H_(2)S

摘要：Taking apart in numerous physiological and pathological activities,hydrogen sulfide(H_(2)S)has been selected as an excellent target spot for the early diagnosis of cancer.So far,there are many mature probes that apply single optical imaging to monitor endogenous H_(2)S.Nevertheless,a single modality is not an ideal method to afford accurate diagnostic information in comprehensive biological organisms.Herein,we developed a dual-modal imaging probe BWS.This designed probe showed a specific response to H_(2)S with both chemiluminescence and NIR fluorescence light-up.The concurrence of fluorescence and chemiluminescence signal provided“double insurances”for highly accurate monitoring of H_(2)S.Satisfactorily,this dual-modal imaging probe performed precise visualization of endogenous H_(2)S in living cells and in vivo.We envisaged that this chemiluminescence/fluorescence real-time dual-modality strategy for H_(2)S detection will expand and optimize the multimodal imaging methods for efficient diagnosis and treatment of cancer.