文献类型：期刊文献

英文题名：Phase Separation in cGAS-STING Signaling: Cytosolic DNA Sensing and Regulatory Functions

作者：Liu, Caixia[1];Yang, Jingyi[1];Zheng, Jiaxin[1];Fu, Jianmian[1];Wang, Weisi[2];Duan, Liping[2];Qian, Xuhong[1,3];Yang, Yangyang[1]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]Natl Inst Parasit Dis, Chinese Ctr Dis Control & Prevent, NHC Key Lab Parasite & Vector Biol, 207 Ruijin Second Rd, Shanghai 200025, Peoples R China;[3]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2023

卷号：24

期号：10

外文期刊名：CHEMBIOCHEM

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000976242700001)】；

基金：This work was supported by the National Natural Science Foundation of China (Grant No. 31600802), the Research Funds of Happiness Flower ECNU (2020JK2103), Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism and Fundamental Research Funds for the Central Universities.

语种：英文

外文关键词：cGAS-STING pathway; DNA sensing; immune response; immunotherapy; phase separation

摘要：Phase separation is a crucial biophysical process that governs cellular signaling and function. This process allows biomolecules to separate and form membraneless compartments in response to both extra- and intra-cellular stimuli. Recently, the identification of phase separation in different immune signaling pathways, including the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway, has shed light on its tight association with pathological processes such as viral infections, cancers, and inflammatory diseases. In this review, we present the phase separation in cGAS-STING signaling, along with its related cellular regulatory functions. Furthermore, we discuss the introduction of therapeutics targeting cGAS-STING signaling, which plays a pivotal role in cancer progression.