文献类型：期刊文献

英文题名：Dilithium Tetrachlorocuprate(II) Catalyzed Oxidative Homocoupling of Functionalized Grignard Reagents

作者：Hua, Si-Kai[2];Hu, Qiu-Peng[2];Ren, Jiangmeng[2];Zeng, Bu-Bing[1,2]

机构：[1]E China Univ Sci & Technol, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China

年份：2013

卷号：45

期号：4

起止页码：518

外文期刊名：SYNTHESIS-STUTTGART

收录：;EI(收录号：20130716025474);WOS:【SCI-EXPANDED(收录号:WOS:000314633000013)，CCR-EXPANDED(收录号:WOS:000314633000013)】；

基金：We are grateful for financial support from the national '863' Project of China (2006AA609Z447 and 2007AA02Z301), the 111 Project (B07023), Shanghai Foundation of Science and Technology (09JC1404200), and The Fundamental Research Funds for the Central Universities (WY1113007).

语种：英文

外文关键词：homocoupling; dilithium tetrachlorocuprate(II); Grignard reagents; oxidant; metalation

摘要：An efficient procedure is described for the oxidative homocoupling of functionalized Grignard reagents using a catalytic amount of dilithium tetrachlorocuprate(II) (CuLi2Cl4) in the presence of pure oxygen gas. This method is applied successfully to a variety of aryl, heteroaryl, alkyl, alkenyl and alkynyl halides, which are converted into the corresponding homocoupled products in good to excellent yields.