文献类型：期刊文献

英文题名：Linkage Chemistry of S(VI) Fluorides

作者：Zeng, Daming[1,2];Deng, Wei-Ping[1];Jiang, Xuefeng[2]

机构：[1]East China Univ Sci & Technol, Shanghai Frontiers Sci Ctr Optogenet Tech Cell Met, Sch Pharm, Shanghai 200237, Peoples R China;[2]East China Normal Univ, Sch Chem & Mol Engn, Shanghai Key Lab Green Chem & Chem Proc, 3663 North Zhongshan Rd, Shanghai 200062, Peoples R China

年份：2023

卷号：29

期号：33

外文期刊名：CHEMISTRY-A EUROPEAN JOURNAL

收录：;EI(收录号：20231814027077);WOS:【SCI-EXPANDED(收录号:WOS:000975681400001)】；

基金：Acknowledgments The authors are grateful for financial support provided by NSFC (22125103 and 21971065), STCSM (20XD1421500 and 20JC1416800), and the Fundamental Research Funds for the Central Universities.

语种：英文

外文关键词：linkage chemistry; S-C bond; S-N bond; S-O bond; SuFEx

摘要：Sulfur(VI)-fluoride exchange linkage as a next generation of click chemistry was introduced by Sharpless and coworkers in 2014. Distinguished from CuAAC, the SuFEx reaction proceeds under metal-free conditions, and the reactive linkers are variable, enabling access to a diverse class of linkage compounds. Therein, a series of SuFEx linkers emerged has been widely prevalent in diverse fields. The S-VI-F bond in comparison to S-VI-Cl bond features excellent stability and chemoselectivity. The linkage chemistry primarily involves the formation of S-O and S-N bonds via commercially available phenols and amines, yet less study on C-SuFEx linkage. This review will focus on three types of linkage for SuFEx linkers comprising S-O, S-N, and S-C bonds, and we hope to provide a practical guidance for SuFEx linkage chemistry.