文献类型：期刊文献

英文题名：Apigenin-7-diglucuronide protects retinas against bright light-induced photoreceptor degeneration through the inhibition of retinal oxidative stress and inflammation

作者：Bian, Minjuan[1,2];Zhang, Yong[3];Du, Xiaoye[1,2];Xu, Jing[4];Cui, Jingang[1,2];Gu, Jiangping[4];Zhu, Weiliang[3];Zhang, Teng[1,2];Chen, Yu[1,2]

机构：[1]Shanghai Univ Tradit Chinese Med, Yueyang Hosp, Shanghai 200437, Peoples R China;[2]Shanghai Univ Tradit Chinese Med, Clin Res Inst Integrat Med, Shanghai 200437, Peoples R China;[3]Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China;[4]East China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China

年份：2017

卷号：1663

起止页码：141

外文期刊名：BRAIN RESEARCH

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000401046500016)】；

基金：This work was supported by the National Natural Science Foundation of China (81473732, 81673790, Y.C); the Program of Eastern Scholar supported by Shanghai Municipal Education Commission (Hu201188, Y.O and GZ2015011, T.Z); the Shuguang Project supported by Shanghai Municipal Education Commission (13SG42, Y. C); the Budget Project from Shanghai Municipal Education Commission (2014YSN49, M.B) and the Shanghai Sailing Program (16YF1414100, Y.Z).

语种：英文

外文关键词：Apigenin-7-diglucuronide; Photoreceptor degeneration; Oxidative stress; Retinal inflammation

摘要：Vision impairment in retinal degenerative diseases such as age-related macular degeneration is primarily associated with photoreceptor degeneration, in which oxidative stress and inflammatory responses are mechanistically involved as central players. Therapies with photoreceptor protective properties remain to be developed. Apigenin-7-diglucuronide (A7DG), a flavonoid glycoside, is present in an assortment of medicinal plants with anti-inflammatory or ant-oxidant activities. However, the pharmacological significance of A7DG remains unknown in vivo. The current study isolated A7DG from Glechoma longituba (Nakai) Kuprian and investigated the retinal protective effect A7DG in mice characterized by bright light-induced photoreceptor degeneration. The results showed that A7DG treatment led to remarkable photoreceptor protection in bright light-exposed BALB/c mice. Moreover, A7DG treatment alleviated photoreceptor apoptosis, mitigated oxidative stress, suppressed reactive gliosis and microglial activation and attenuated the expression of proinflammatory genes in bright light-exposed retinas. The results demonstrated for the first time remarkable photoreceptor protective activities of A7DG in vivo. Inhibition of bright light-induced retinal oxidative stress and retinal inflammatory responses was associated with the retinal protection conferred by A7DG. The work here warrants further evaluation of A7DG as a pharmacological candidate for the treatment of vision-threatening retinal degenerative disorders. Moreover, given the general implication of oxidative stress and inflammation in the pathogenesis of neurodegeneration, A7DG could be further tested for the treatment of other neurodegenerative disorders. (C) 2017 Elsevier B.V. All rights reserved.