文献类型：期刊文献

英文题名：Gradiently degraded electrospun polyester scaffolds with cytostatic for urothelial carcinoma therapy

作者：Wang, Jixue[1,2];Wang, Guanyu[3];Shan, Hongli[4];Wang, Xiaoqing[1];Wang, Chunxi[1];Zhuang, Xiuli[2,5];Ding, Jianxun[2,5];Chen, Xuesi[2,5]

机构：[1]Jilin Univ, Hosp 1, Dept Urol, Changchun 130021, Jilin, Peoples R China;[2]Chinese Acad Sci, Changchun Inst Appl Chem, Key Lab Polymer Ecomat, Changchun 130022, Jilin, Peoples R China;[3]East China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai 200237, Peoples R China;[4]Jilin Univ, Hosp 1, Dept Clin Lab, Changchun 130021, Jilin, Peoples R China;[5]Jilin Biomed Polymers Engn Lab, Changchun 130022, Jilin, Peoples R China

年份：2019

卷号：7

期号：3

起止页码：963

外文期刊名：BIOMATERIALS SCIENCE

收录：;EI(收录号：20191006586333);WOS:【SCI-EXPANDED(收录号:WOS:000463226900019)】；

基金：This study was financially supported by the National Natural Science Foundation of China (No. 51873207, 51773083, 51673190, 51673187, 51603204, 51503076, 51520105004, and 51473165), the National Key Research and Development Program of China (Grant No. 2016YFC1100700 and 2016YFC1100701), and the Science and Technology Development Program of Jilin Province (No. 2016J059, 20160204015SF, and 20180101200JC).

语种：英文

外文关键词：Scaffolds - Targeted drug delivery - Controlled drug delivery - Drug products - Scaffolds (biology)

摘要：Kidney-sparing surgery is the preferred treatment strategy for low-risk upper tract urothelial carcinoma (UTUC). However, after this procedure, prevention of the carcinoma recurrence in the ureter and supporting the ureter with a ureteral stent are necessary. Biodegradable drug-loaded ureteral scaffolds are able to maintain their long-term effective drug concentrations in the lesion sites without the defects of traditional ureteral stents, which may address both issues simultaneously. The purpose of this study was to reveal the possibility of the controlled delivery of epirubicin (EPI) via gradiently degraded electrospun poly(epsilon-caprolactone) (PCL)/poly(lactide-co-glycolide) (PLGA) scaffolds to evaluate their antitumor activity against UTUC. The degradable PCL/PLGA scaffolds containing 15.0 and 25.0 wt% PCL and loading of 0, 5.0, and 10.0 wt% EPI were successfully fabricated via electrospinning. In addition, the PCL/PLGA scaffolds showed sustained and controlled degradation and drug release kinetics, that is, their degradation and drug release rates slowed with an increase in the ratio of PCL. The EPI-loaded PCL/PLGA scaffolds showed excellent antitumor activities both in vitro and in vivo without apparent systemic toxicity. Overall, the gradiently-degraded EPI-loaded electrospun polyester scaffolds are potential ureteral stent tubes for the local inhibition of the recurrence of UTUC, where the continued release of EPI can prevent the subsequent proliferation of residual tumor cells, and the gradient degradation is consistent with the repair of the ureter.