文献类型：期刊文献

英文题名：Host defense peptide-mimicking peptide polymer-based antibacterial hydrogel enables efficient healing of MRSA-infected wounds

作者：Qiao, Zhongqian[1];Zhang, Wenjing[1,3];Wu, Yueming[2];Jiang, Weinan[2];Shao, Ning[2];Xie, Jiayang[2];Xia, Guixue[2];Chen, Qimeng[2];Liu, Zhefeng[2];Zou, Jingcheng[2];Gu, Jiawei[2];Luan, Shifang[4];Lin, Haodong[3];Liu, Runhui[1,2]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Shanghai Frontiers Sci Ctr Optogenet Tech Cell Met, Res Ctr Biomed Mat,Minist Educ,Key Lab Ultrafine M, Shanghai 200237, Peoples R China;[3]Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Sch Med, Dept Orthoped Surg, Shanghai 200080, Peoples R China;[4]Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China

年份：2023

卷号：66

期号：6

起止页码：1824

外文期刊名：SCIENCE CHINA-CHEMISTRY

收录：;EI(收录号：20232114112084);WOS:【SCI-EXPANDED(收录号:WOS:000988378800001)】；

基金：This work was supported by the National Natural Science Foundation of China (22075078, 52203162), the Program of Shanghai Academic/Technology Research Leader (20XD1421400), Shanghai Sailing Program (21YF1409100), China National Postdoctoral Program for Innovative Talents (BX20220108), the China Postdoctoral Science Foundation (2021M701198), the Open Research Fund of State Key Laboratory of Polymer Physics and Chemistry (Changchun Institute of Applied Chemistry, Chinese Academy of Sciences), and the Frontier Science Research Base of Optogenetic Techniques for Cell Metabolism (2021 Sci & Tech 03-28, Shanghai Municipal Education Commission). We thank the Research Center of Analysis and Test of East China University of Science and Technology for the help with the characterization.

语种：英文

外文关键词：peptide polymer; wound healing; MRSA; drug-resistance; host defense peptide

摘要：Wound infections are a compelling health issue caused by the invasion and proliferation of pathogens in wound sites. Antibiotic-loaded hydrogels are widely used to achieve anti-infectious wound healing. However, due to the quick emergence of drug-resistant bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA), wound infection has been a formidable challenge to human health. To address MRSA-infected wounds, an antibacterial peptide polymer-loaded hyaluronic acid (HA) hydrogel (Gel-HA@P) is prepared. The peptide polymer is designed to mimic host defense peptides as the antibiotic alternative showing potent antibacterial activity, low susceptibility to drug resistance and good stability against proteolysis. HA is biocompatible and biodegradable hydrogel substrate as a primary constituent of the extracellular matrix and suitable for cell migration and wound healing. Gel-HA@P shows potent activity against MRSA in vitro and in vivo, low toxicity during the treatment and promotes the wound healing in vivo. This design has proven to be an effective and antibiotic-free strategy to enable the healing of MRSA-infected wounds.