文献类型：期刊文献

英文题名：Controllable Structure and Fluorescence Enhancement of ACQ Dye Nanoparticles Based on the FNP Process

作者：Wu, Yue[1];Zhang, Yutao[2,3];Guo, Zhiqian[2,3];Xu, Yisheng[1]

机构：[1]East China Univ Sci & Technol, Ctr Photosensit Chem Engn, Sch Chem Engn, State Key Lab Green Chem Engn & Ind Catalysis, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Inst Fine Chem, Feringa Nobel Prize Scientist Joint Res Ctr, Sch Chem & Mol Engn,Key Lab Adv Mat, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Tec hnol, Feringa Nobel Prize Scientist Joint Res Ctr, Joint Int Res Lab Precis Chem & Mol Engn, Inst Fine Chem,Sch Chem & Mol Engn, Shanghai 200237, Peoples R China

年份：2025

卷号：17

期号：15

外文期刊名：POLYMERS

收录：;EI(收录号：20253318986686);WOS:【SCI-EXPANDED(收录号:WOS:001548692700001)】；

基金：This research was financially supported by the National Natural Science Foundation of China (22378126, 22225805, 32394001, and 32121005), National Key Research and Development Program (2023YFA1802000), and Science and Technology Innovation Plan of Shanghai Science and Technology Commission (22501100500).

语种：英文

外文关键词：fluorescence nanoparticles; ACQ effect; flash nanoprecipitation; fluorescence enhancement

摘要：Fluorescent dyes, such as cyanine dyes, are widely used in fluorescence-imaging-guided tumor therapy due to their high absorbance and fluorescence quantum yield. However, challenges persist in optimizing the performance of fluorescent nanoparticles, particularly due to the aggregation-caused quenching (ACQ) effect of cyanine dyes. Here, a novel counterion construction strategy is introduced using cyanine dye as a model ACQ dye. Through dynamic-controlled flash nanoprecipitation, fluorescent nanoparticles (CyINPs) with tunable structures are developed, investigating the effects of various factors, including counterions, block copolymers, and dye concentrations, on CyINPs' stability and fluorescence enhancement. The optimized CyINPs with good water solubility show a 21-fold increase in fluorescence intensity and a 3.5-fold increase in encapsulation efficiency compared to CyINPs prepared by a thermodynamic-driven method. Under the efforts of polymers and counterions, dyes are separated, which reduces the impact of the ACQ effect and results in stronger fluorescence intensity, providing insights into improving nanoparticle biocompatibility and energy utilization efficiency.