文献类型：期刊文献

英文题名：Long conjugated 2-nitrobenzyl derivative caged anticancer prodrugs with visible light regulated release: preparation and functionalizations

作者：Bao, Chunyan[2];Jin, Ming[1];Li, Bo[3];Xu, Yaodong[2];Jin, Jingyan[2];Zhu, Linyong[2]

机构：[1]Tongji Univ, Sch Mat Sci & Engn, Inst Funct Polymer Mat, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Inst Fine Chem, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China;[3]E China Normal Univ, Dept Elect Engn, Minist Educ, Key Lab Polar Mat & Devices, Shanghai 200241, Peoples R China

年份：2012

卷号：10

期号：27

起止页码：5238

外文期刊名：ORGANIC & BIOMOLECULAR CHEMISTRY

收录：;EI(收录号：20122715193543);WOS:【SCI-EXPANDED(收录号:WOS:000305480400012)】；

基金：This work was supported by NSFC (20902069, 20903039, 21173078), "Chen Guang" project (09CG25), Shanghai Sci. Tech. Comm. (11JC1403300), and Fundamental Research Funds for the Central University.

语种：英文

外文关键词：Photons - Light - Targeted drug delivery

摘要：A series of anticancer prodrugs with different chemical functional groups were prepared, in which the styryl conjugated 2-nitrobenzyl derivatives were introduced as the phototrigger to regulate the drug (chlorambucil) release. Compared to the common 4,5-dimethoxy-2-nitrobenzyl caged compounds, most of the prodrugs exhibited large and redshifted one-photon absorption within the visible range. One-photon excitation for the drug release was studied by measuring UV-vis absorption, FT-IR, and HPLC spectra, which suggested that chlorambucil was released effectively and precisely by manipulating external light conditions. And the introduction of different functional groups made this type of prodrug a good platform to further react with some typical drug carriers and to further form excellent visible light responsive drug delivery systems. Moreover, the drug also could be effectively released under the excitation of two-photon at 800 nm with comparable photorelease efficiencies.