文献类型：期刊文献

英文题名：Recent developments in multimodality fluorescence imaging probes

作者：Zhao, Jianhong[1,2];Chen, Junwei[1,2];Ma, Shengnan[1,2];Liu, Qianqian[1,2];Huang, Lixian[1,2];Chen, Xiani[1,2];Lou, Kaiyan[1,2];Wang, Wei[1,2,3]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, State Key Lab Bioengn Reactor, Shanghai 200237, Peoples R China;[3]Univ New Mexico, Dept Chem & Chem Biol, Albuquerque, NM 87131 USA

年份：2018

卷号：8

期号：3

起止页码：320

外文期刊名：ACTA PHARMACEUTICA SINICA B

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000433342600002)】；

基金：The work was supported by the National Science Foundation of China (No. 21577037 to Kaiyan Lou), and East China University of Science and Technology (Grant No. YC0140101, start-up funds to Wei Wang).

语种：英文

外文关键词：Optical imaging; Fluorescence; Multimodality; Near-infrared fluorescence; Nanoprobe; Computedtomography; Magneticresonance imaging; Positronemissiontomo graphy; Single-photonemission computedtomography; Photoacoustic imaging

摘要：Multimodality optical imaging probes have emerged as powerful tools that improve detection sensitivity and accuracy, important in disease diagnosis and treatment. In this review, we focus on recent developments of optical fluorescence imaging (OFT) probe integration with other imaging modalities such as X-ray computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography (PET), single-photon emission computed tomography (SPECT), and photoacoustic imaging (PAI). The imaging technologies are briefly described in order to introduce the strengths and limitations of each techniques and the need for further multimodality optical imaging probe development. The emphasis of this account is placed on how design strategies are currently implemented to afford physicochemically and biologically compatible multimodality optical fluorescence imaging probes. We also present studies that overcame intrinsic disadvantages of each imaging technique by multimodality approach with improved detection sensitivity and accuracy. (C) 2018 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.