文献类型：期刊文献

英文题名：Solvent-free base-controlled addition reaction of H-phosphonates and H-phosphine oxides to α-CF3 styrenes: facile synthesis of β-CF3-substituted phosphonates and phosphine oxides

作者：Zeng, Qianding[1];Liu, Ying[1];He, Jingjing[1];Deng, Yupian[1];Zheng, Pai[1];Sun, Zhudi[1];Cao, Song[1,2]

机构：[1]East China Univ Sci & Technol ECUST, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China;[2]Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China

年份：2023

卷号：21

期号：24

起止页码：4982

外文期刊名：ORGANIC & BIOMOLECULAR CHEMISTRY

收录：;EI(收录号：20232414229374);WOS:【SCI-EXPANDED(收录号:WOS:001000916000001)，CCR-EXPANDED(收录号:WOS:001000916000001)】；

语种：英文

外文关键词：Addition reactions - Phosphorus compounds

摘要：A practical and efficient solvent-free synthesis of beta-trifluoromethyl-substituted phosphonates and phosphine oxides via hydrophosphonylation and hydrophosphinylation of alpha-(trifluoromethyl)styrenes with H-phosphonates and H-phosphine oxides, respectively, was developed. The reaction proceeded smoothly within 2 h at room temperature without the cleavage of the rather fragile C-F bond in alpha-(trifluoromethyl)styrenes and afforded a wide variety of structurally diverse and valuable beta-trifluoromethyl-containing phosphonates and phosphine oxides in moderate to good yields. This protocol features mild conditions, wide substrate scope, simple manipulation, and excellent functional group compatibility.