文献类型：期刊文献

英文题名：Enantioselective direct vinylogous aldol-cyclization cascade reaction between β,γ-unsaturated amides and o-quinones

作者：Jiang, Yu;Fu, Jun-Hao;Li, Tian-Ze;Sha, Feng[1];Wu, Xin-Yan[1]

机构：[1]East China Univ Sci & Technol, Key Lab Adv Mat A, 130 Meilong Rd, Shanghai 200237, Peoples R China; East China Univ Sci & Technol, Inst Fine Chem, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2016

卷号：14

期号：27

起止页码：6435

外文期刊名：ORGANIC & BIOMOLECULAR CHEMISTRY

收录：;EI(收录号：20162902594041);WOS:【SCI-EXPANDED(收录号:WOS:000380329100012)，CCR-EXPANDED(收录号:WOS:000380329100012)】；

基金：We are grateful for the financial support from the National Natural Science Foundation of China (21102043), the Science and Technology Commission of Shanghai Municipality (15ZR1409200), and the Fundamental Research Funds for the Central Universities.

语种：英文

外文关键词：Condensation reactions - Enantioselectivity - Amides - Ketones

摘要：1,2-Diketones are employed, for the first time, as electrophiles in the vinylogous aldol reaction. With 5 mol% of chiral tertiary amine-thiourea C8, a direct vinylogous aldol-cyclization cascade reaction between beta,gamma-unsaturated amides and o-quinones has been achieved to produce spirocyclic dihydropyranones in 76-99% yield and 82-95% ee.