文献类型：期刊文献

英文题名：Enzymatically extracted rose bee pollen significantly alleviates BPH and hyperlipidemia-aggravated progression by targeting COX-2 inhibition

作者：Sun, Yishu[1];Xiong, Fangci[1];Chen, Zitian[1];Wang, Zhisheng[1];Lu, Xinyang[1];Meng, Xiangchun[1];Chang, Yaning[1];Zhou, Yingjun[1]

机构：[1]East China Univ Sci & Technol, Sch Biotechnol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

年份：2025

卷号：72

外文期刊名：FOOD BIOSCIENCE

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001564556700002)】；

语种：英文

外文关键词：Rose bee pollen; Enzymatic wall-breaking; Benign prostatic hyperplasia; COX-2; Hyperlipidemia; Transcriptome analysis

摘要：Benign prostatic hyperplasia (BPH) is a critical age-related urological condition, which is often aggravated by obesity. Rose bee pollen, a traditional edible substance rich in free phenolic acids and flavonoids remains understudied for BPH. In this study, we confirmed its anti-BPH efficacy through both BPH-1 cells and TP-induced mice models. Firstly, we demonstrated that the enzymatically treated rose bee pollen extract (EEBP) targets cyclooxygenase-2 (COX-2), downregulates prostaglandin E2 (PGE2), and inhibits the ERK1/2-NF-kappa B pathway, thereby suppressing growth factor expression in BPH model. Importantly, EEBP inhibited the COX-2 protein expression in BPH mice by approximately 85.8 %. Furthermore, we identified isorhamnetin, quercetin, and pelargonidin as the key bioactive components in EEBP through a combination of UHPLC-MS, transcriptomic analysis, and molecular docking screening. Notably, EEBP exerts anti-BPH activity in hyperlipidemia-aggravated condition through dual COX-2 inhibition and antioxidant activity. In conclusion, our research provides new insights into the anti-BPH efficacy mechanism of rose bee pollen and its clinical application in cases complicated with hyperlipidemia.