文献类型：专利

英文题名：Preparation of 3-(4-chlorobutyl)-1H-indole-5-carbonitrile involves reacting sulfate group-containing compound with 1-chloro-4-bromo or iodobutane, and hydrolyzing butyl chloride compound in presence of alkali medium

作者：GUO J;HUANG R;SHEN Y;SHI J;TAO J;WANG C;ZHOU C

机构：[1]UNIV EAST CHINA SCI & TECHNOLOGY;[2]NANTONG HENGSHENG FINE CHEM CO LTD

申请号：CN103709089-A

申请日：2013-12-31

公开日：2014-04-09

语种：英文

收录：DERWENT

摘要：NOVELTY - 5-Cyano indole ring and sulfonic acid compound (II) are reacted, to obtain sulfate group-containing compound (III). The sulfate group-containing compound (III) is reacted with 1-chloro-4-bromo or iodobutane to obtain butyl chloride compound (IV). The butyl chloride compound (IV) is hydrolyzed in presence of alkali medium, to obtain 3-(4-chlorobutyl)-1H-indole-5-carbonitrile (I). USE - Preparation of 3-(4-chlorobutyl)-1H-indole-5-carbonitrile (claimed). ADVANTAGE - The method provides 3-(4-chlorobutyl)-1H-indole-5-carbonitrile having high reaction selectivity without using expensive catalyst, with yield of 75.3%, by a controllable process. DETAILED DESCRIPTION - 5-Cyano indole ring and sulfonic acid compound of formula (II) are reacted, to obtain sulfate group-containing compound of formula (III). The sulfate group-containing compound (III) is reacted with 1-chloro-4-bromo or iodobutane to obtain butyl chloride compound of formula (IV). The butyl chloride compound (IV) is hydrolyzed in presence of alkali medium, to obtain 3-(4-chlorobutyl)-1H-indole-5-carbonitrile of formula (I). R=nitro or cyano;and X=Cl, or Br.