文献类型：期刊文献

英文题名：Synthesis and Nematicidal Activities of 1,2,3-Benzotriazin-4-one Derivatives against Meloidogyne incognita

作者：Wang, Gaolei[1];Chen, Xiulei[1];Deng, Yayun[1];Li, Zhong[1,2];Xu, Xiaoyong[1,2]

机构：[1]E China Univ Sci & Technol, Shanghai Key Lab Chem Biol, Sch Pharm, Shanghai 200237, Peoples R China;[2]Shanghai Collaborat Innovat Ctr Biomfg Technol, Shanghai 200237, Peoples R China

年份：2015

卷号：63

期号：31

起止页码：6883

外文期刊名：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

收录：;EI(收录号：20153201122256);WOS:【SCI-EXPANDED(收录号:WOS:000359613400005)】；

基金：This work was financial supported by the National Natural Science Foundation of China (21272071) and the National High Technology Research and Development Program of China (863 Program, 2011AA10A207 and 2013AA065202). This work was also partly supported by the Special Fund for Agro-scientific Research in the Public Interest (201103007) and the Fundamental Research Funds for the Central Universities.

语种：英文

外文关键词：1,2,3-benzotriazin-4-one; 2-cyanoiminothiazolidin-4-one; nematicide; Meloidogyne incognita; in vivo

摘要：A series of novel 1,2,3-benzotriazin-4-one derivatives were synthesized by the reaction of 3-bromoalky1-1,2,3-benzotriazin-4-ones with potassium salt of 2-cyanoimino-4-oxothiazolidine in the presence of potassium iodide. Nematicidal assays in vivo showed that some of them exhibited good control efficacy against the cucumber root-knot nematode disease caused by Meloidogyne incognita, up to 100% at the concentration of 10.0 mg L-1, which indicated that 1,2,3-benzotriazin-4-one derivatives might be potential for novel promising nematicides. The nematicidal activity was influenced by the combination of substituent type, substituted position, and linker length in the molecule. The inhibition rate data at the concentrations of 5.0 and 1.0 mg L-1 for the compounds with high inhibitory activities were also provided. When tested in vitro, none of them showed direct inhibition against M. incognita. The investigation of a significant difference between in vivo and in vitro data is in progress.