文献类型：期刊文献

英文题名：Metal-based imaging agents: progress towards interrogating neurodegenerative disease

作者：Sedgwick, Adam C.[1];Brewster, James T., II[1];Harvey, Peter[2,3];Iovan, Diana A.[4];Smith, Graham[5];He, Xiao-Peng[6,7];Tian, He[6,7];Sessler, Jonathan L.[1];James, Tony D.[8]

机构：[1]Univ Texas Austin, Dept Chem, Austin, TX 78712 USA;[2]MIT, Dept Biol Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA;[3]Univ Nottingham, Sch Med, Div Clin Neurosci, Sir Peter Mansfield Imaging Ctr, Nottingham NG7 2RD, England;[4]Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA;[5]Inst Canc Res, Div Radiotherapy & Imaging, 123 Old Brompton Rd, London SW7 3RP, England;[6]East China Univ Sci & Technol, Sch Chem & Mol Engn, Feringa Nobel Prize Scientist Joint Res Ctr, Key Lab Adv Mat, 130 Meilong Rd, Shanghai 200237, Peoples R China;[7]East China Univ Sci & Technol, Sch Chem & Mol Engn, Feringa Nobel Prize Scientist Joint Res Ctr, Joint Int Res Lab Precis Chem & Mol Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China;[8]Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England

年份：2020

卷号：49

期号：10

起止页码：2886

外文期刊名：CHEMICAL SOCIETY REVIEWS

收录：;EI(收录号：20202408809555);WOS:【SCI-EXPANDED(收录号:WOS:000537849300001)】；

基金：DAI thanks the Life Sciences Research Foundation for a postdoctoral fellowship sponsored by the Howard Hughes Medical Institute. PH thanks the University of Nottingham for support through a Nottingham Research Fellowship. XPH would like to thank The National Key Sci-Tech Special Projects of Infectious Diseases of China (2018ZX10732202). XPH and HT thank financial support from Natural Science Foundation of China (No. 21788102, 91853201, 21722801 and 21776078) and the Shanghai Municipal Science and Technology Major Project (No. 2018SHZDZX03). A. C. S. and J. T. B. would like to thank Gregory D. Thiabaud (UT Austin) for helpful discussions. JLS would like to thank the National Institutes of Health (grant CA 68682) and the Robert A. Welch Foundation (F-0018) for support. TDJ wishes to thank the Royal Society for a Wolfson Research Merit Award.

语种：英文

外文关键词：Biomarkers - Diagnosis - Transition metals - Magnetic resonance imaging - Molecular imaging - Positron emission tomography - Single photon emission computed tomography - Luminescence - Binding energy - Particle beams

摘要：Central nervous system (CNS) neurodegeneration is defined by a complex series of pathological processes that ultimately lead to death. The precise etiology of these disorders remains unknown. Recent efforts show that a mechanistic understanding of the malfunctions underpinning disease progression will prove requisite in developing new treatments and cures. Transition metals and lanthanide ions display unique characteristics (i.e., magnetism, radioactivity, and luminescence), often with biological relevance, allowing for direct application in CNS focused imaging modalities. These techniques include positron emission tomography (PET), single-photon emission computed tomography (SPECT), magnetic resonance imaging (MRI), and luminescent-based imaging (LumI). In this Tutorial Review, we have aimed to highlight the various metal-based imaging techniques developed in the effort to understand the pathophysiological processes associated with neurodegeneration. Each section has been divided so as to include an introduction to the particular imaging technique in question. This is then followed by a summary of key demonstrations that have enabled visualization of a specific neuropathological biomarker. These strategies have either exploited the high binding affinity of a receptor for its corresponding biomarker or a specific molecular transformation caused by a target species, all of which produce a concomitant change in diagnostic signal. Advantages and disadvantages of each method with perspectives on the utility of molecular imaging agents for understanding the complexities of neurodegenerative disease are discussed.