文献类型：期刊文献

英文题名：Antitumor and immunomodulatory activities of a polysaccharide from Artemisia argyi

作者：Bao, Xiaoli[1,2];Yuan, Huihui[3];Wang, Chengzhong[1,2];Liu, Jinjin[1,2];Lan, Minbo[1,2,4]

机构：[1]E China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Res Ctr Anal & Test, Shanghai 200237, Peoples R China;[3]E China Univ Sci & Technol, Inst Appl Chem, Shanghai 200237, Peoples R China;[4]E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

年份：2013

卷号：98

期号：1

起止页码：1236

外文期刊名：CARBOHYDRATE POLYMERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000325835600160)】；

基金：This work was supported by the Science and Technology Commission of Shanghai Municipality (STCSM, Contract No. 11nm0505700).

语种：英文

外文关键词：Artemisia argyi; Polysaccharide; Antitumor; Immunomodulation

摘要：A water-soluble polysaccharide (FAAP-02), composed of N-acetyl-D-glucosamine, glucose, mannose, galactose, rhamnose, arabinose, xylose and ribose, with an average molecular weight of 5169 Da, was isolated from Artemisia argyi. The antitumor and immunomodulatory activities of FAAP-02 were evaluated in Sarcoma 180 (S180) tumor-bearing mice by intraperitoneal administration. As a result, FAAP-02 significantly inhibited the growth of the S180 transplanted tumors and prolonged the survival time of the tumor-bearing mice. Moreover, FAAP-02 could obviously increase the thymus and spleen indices, the levels of serum Interleukin 2 (IL-2), Interleukin 6 (IL-6), Interleukin 12 (IL-12) and tumor necrosis factor-alpha (TNF-alpha) and the expression of CD4+ and CD8+ splenic T lymphocytes which were suppressed by the transplanted tumor or/and 5-fluorouracil (5-FU) in the mice. These results indicated that the antitumor activity of FAAP-02 might be associated with its immunostimulatory effects. (C) 2013 Elsevier Ltd. All rights reserved.