文献类型：期刊文献

英文题名：Hepatoprotective Effects of 2′,4′-Dihydroxy-6′-methoxy-3′,5′-dimethylchalcone on CCl₄-Induced Acute Liver Injury in Mice

作者：Yu, Wan-Guo[1];Qian, Jie[2];Lu, Yan-Hua[1]

机构：[1]E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]Tongji Univ, Sch Life Sci & Technol, Shanghai 200092, Peoples R China

年份：2011

卷号：59

期号：24

起止页码：12821

外文期刊名：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000298215100012)】；

基金：This work was supported by the National Natural Science Foundation of China (No. 30870253), and partially supported by Shanghai Leading Academic Discipline Project (B505), the National Special Fund for State Key Laboratory of Bioreactor Engineering (2060204), and the 863 Project (2011AA090702).

语种：英文

外文关键词：2 ',4 '-dihydroxy-6 '-methoxy-3 ',5 '-dimethylchalcone; hepatoprotective effects; hepatotoxicity; lipid peroxidation; mice; oxidative stress

摘要：In this paper, the hepatoprotective effects of 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone (DMC) on CCl4-induced acute liver injury in Kunming mice were investigated. DMC was administered intraperitoneally (ip) (5, 10, or 20 mg/kg of body weight) for 7 days prior to the administration of CCl4 (0.1%, ip). Pretreatment with DMC significantly decreased activities of serum hepatic enzymes, namely alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, alkaline phosphatase, gamma-glutamyl transferase, and total bilirubin, and decreased the elevation of lipid peroxidation, malondialdehyde, reactive oxygen species, and protein carbonyl content. Pretreatment with DMC markedly increased activities of enzymatic antioxidants such as superoxide dismutase, catalase, glucose-6-phosphate dehydrogenase, glutathione peroxidase, glutathione S-transferase, and glutathione reductase and increased levels of nonenzymatic antioxidant markers such as reduced glutathione, total sulfhydryl groups, vitamin C, and vitamin E in liver. These results combined with liver histopathology demonstrate that DMC has potential hepatoprotective effects, which may be related to the attenuation of oxidative stress, accelerating the antioxidant cascade and inhibition of lipid peroxidation.