文献类型：期刊文献

英文题名：K₂CO₃-assisted one-pot sequential synthesis of 2-trifluoromethyl-6-difluoromethylpyridine-3,5-dicarboxylates under solvent-free conditions

作者：Shen, Li[1];Cao, Song[1];Wu, Jingjing[1];Li, Hui[1];Zhang, Jian[1];Wu, Mingxi[1];Qian, Xuhong[1]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Ctr Fluorine Chem Technol, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China

年份：2010

卷号：51

期号：37

起止页码：4866

外文期刊名：TETRAHEDRON LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000281356700021)，CCR-EXPANDED(收录号:WOS:000281356700021)】；

基金：We are grateful for the financial supports from the National Basic Research Program of China (973 Program, 2010CB126101), the Shanghai Foundation of Science of Technology (09391911800), and the Shanghai Leading Academic Discipline Project (B507).

语种：英文

摘要：A novel synthesis of 2-trifluoromethyl-6-difluoromethylpyridine-3,5-dicarboxylates by three-component reaction of ethyl trifluoroacetoacetate, aldehydes, and ammonium acetate in the presence of K2CO3 under solvent-free conditions via sequential Hantzsch reaction/dehydration/dehydrofluorination in a one-pot process was described. (C) 2010 Elsevier Ltd. All rights reserved.