文献类型：期刊文献

英文题名：Modular Access to Diverse Bridged Indole Alkaloid Mimics via a Gold-Triggered Cascade Dearomative Spirocarbocyclization/[4+2] Cycloaddition Sequence

作者：He, Yi[1];Liu, Zhen[2];Wu, Danjun[3];Li, Zhenghua[1];Robeyns, Koen[4];Van Meervelt, Luc[5];Van der Eycken, Erik V.[1,6]

机构：[1]Katholieke Univ Leuven, Dept Chem, LOMAC, Celestijnenlaan 200F, B-3001 Leuven, Belgium;[2]East China Univ Sci & Technol, State Key Lab Chem Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China;[3]Zhejiang Univ Technol, Coll Pharmaceut Sci, 18 Chaowang Rd, Hangzhou 310014, Zhejiang, Peoples R China;[4]Catholic Univ Louvain, Inst Condensed Matter & Nanosci IMCN, 1 Pl Louis Pasteur, B-1348 Louvain La Neuve, Belgium;[5]Katholieke Univ Leuven, Dept Chem, Biomol Architecture, Celestijnenlaan 200F, B-3001 Leuven, Belgium;[6]RUDN Univ, Peoples Friendship Univ Russia, 6 Miklukho Maklaya St, Moscow 117198, Russia

年份：2019

卷号：21

期号：12

起止页码：4469

外文期刊名：ORGANIC LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000473116000016)】；

基金：This work was financially supported by the FWO [Fund for Scientific Research-Flanders (Belgium)], the Research Fund of the University of Leuven (KU Leuven), and RUDN University Program 5-100. Y.H. appreciates the China Scholarship Council (CSC) for providing a doctoral fellowship. L.V.M. thanks the Hercules Foundation for supporting the purchase of a diffractometer through project AKUL/09/0035. All authors thank Prof. Bert Sels at the Center for Surface Chemistry and Catalysis, KU Leuven, for providing the hydrogenation apparatus.

语种：英文

摘要：A modular and streamlined synthetic strategy for the generation of bridged indole alkaloid-like heterocycles from easily available building blocks is elaborated. This approach utilizes an Ugi four-component reaction, establishing diversity, followed by an efficient cationic gold-triggered intramolecular cascade non-oxidative dearomative spirocarbocyclization/concerted [4 + 2] cyclization cascade, furnishing these architecturally complex and distinct bridged heterocyclic scaffolds with good diastereoselectivity.