文献类型：期刊文献

英文题名：Preparation, microstructure and function of liposome with light responsive switch

作者：Liu, Yangyang[1];An, Xueqin[1]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2019

卷号：178

起止页码：238

外文期刊名：COLLOIDS AND SURFACES B-BIOINTERFACES

收录：;EI(收录号：20191106625748);WOS:【SCI-EXPANDED(收录号:WOS:000471084400029)】；

基金：This research was supported by the National Natural Science Foundation of China (21473055 and 21773064).

语种：英文

外文关键词：Liposomes; Light responsive switch; Microstructure; Drug delivery; Control release; Reversibility of structural isomerization

摘要：A novel liposome with photo-responsiveness was prepared by a combined method of thin film hydration and supercritical carbon dioxide technique. In liposomes, curcumin and 4-butylazobenzene-4-hexyloxy-trimethyl-ammo-niumtrifluoro-acetate (BHA) were used as model drug and photo-responsive reversible switch, respectively. Optimum incubation temperature of drug was determined by using phase transition temperature of the liposomes. Morphology and size of liposomes were obtained by transmission electron microscope and dynamic light scattering technology. Microstructure of liposomes was explored by fluorescent probes, and it was found that the BHA was encapsulated in polar groups of phospholipid in the bilayer of liposomes. Light responsiveness and reversibility of BHA in liposomes were studied from the viewpoint of the microstructure and the macro property. It was shown that the reversibility of structural isomerization of BHA can be used as photo-responsive switch to control drug release.