文献类型：期刊文献

英文题名：Synthesis of Chiral Porous Organic Polymers Through Nucleophilic Substitution for Chiral Separation

作者：Wu, Ziqi[1];Li, Tianlu[1];Ding, Yun[1];Hu, Aiguo[1]

机构：[1]East China Univ Sci & Technol, Shanghai Key Lab Adv Polymer Mat, Sch Mat Sci & Engn, Shanghai 200237, Peoples R China

年份：2020

卷号：2

期号：12

起止页码：5414

外文期刊名：ACS APPLIED POLYMER MATERIALS

收录：;EI(收录号：20211110092971);WOS:【SCI-EXPANDED(收录号:WOS:000599602200011)】；

基金：The authors gratefully acknowledge the financial support from the National Natural Science Foundation of China (21674035), the Fundamental Research Funds for the Central Universities (22221818014), and the Shanghai Leading Academic Discipline Project (B502). A.H. thanks the "Eastern Scholar Professorship" support from Shanghai local government.

语种：英文

外文关键词：porous organic polymer; chirality; enantioselective adsorption; chiral stationary phase; enantioseparation

摘要：A chiral porous organic polymer (cPOP) was synthesized from chiral 1,2-bis(3,4-dichloromaleimide)cyclohexane and 1,3,5-tri(4-aminophenyl)benzene through facile and catalyst-free nucleophilic substitution reactions. The resulting cPOP consisted multistage porous structures with a BET specific surface area of 404 m(2)/g. It showed a high thermal stability as indicated by thermogravimetric analysis. A series of secondary alcohols were enantioselectively adsorbed by the cPOP to achieve enantiomeric excess (ee) values up to 72%. To be further used for liquid chromatography separation, a one-pot method was designed to attach the cPOP onto silica particles to fabricate the SiO2@cPOP composite with a regular shape and uniform size. The racemic mixture of alpha-(1-naphthyl)-ethanol was successfully separated on a simulated liquid chromatography column with SiO2@cPOP as the stationary phase to give single enantiomers at the forefront and at the end of the elution. The features of good resolution performances, simple operating procedure, and facile synthetic conditions would endow the cPOP with potential applications in practical chiral separation of racemates.