文献类型：期刊文献

英文题名：Characterization of ibuprofen microparticle and improvement of the dissolution

作者：Ren, Fuzheng[1,2];Su, Jianping[1,2];Xiong, Hui[1,2];Tian, Ying[1,2];Ren, Guobin[1,2];Jing, Qiufang[1,2]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Dept Pharmaceut Engn, Lab Pharmaceut Crystal Engn & Technol, Shanghai, Peoples R China;[2]East China Univ Sci & Technol, Sch Pharm, 363,No 130,Meilong Rd, Shanghai, Peoples R China

年份：2017

卷号：22

期号：1

起止页码：63

外文期刊名：PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000394644600008)】；

基金：The authors would like to thank the supports from the Shanghai Committee of Science and Technology (Grant 14DZ1930800).

语种：英文

外文关键词：Cremophor RH40; dissolution; ibuprofen; microparticle; Tween 80

摘要：The objective of this study was to prepare ibuprofen (IBP) microparticles by pH-change method and enhance the dissolution rate in vitro. Tween80 and Cremophor RH40 were selected as stabilizers to change the microparticles morphology. The microparticles were evaluated by dissolution profiles and characterized by differential scanning calorimetry (DSC), powder X-ray diffraction (XRD), laser particle size analyzer, scanning electron microscope (SEM) and Fourier transform infrared spectroscopy (FTIR). IBP microparticle prepared with surfactants showed a significant increase in dissolution rate (more than three times within 10min) and an obvious decrease in mean particle size. The morphology of microparticles was obviously changed. XRD and DSC results revealed that the crystalline state of the untreated IBP and the prepared IBP microparticles were similar. The crystallinity of microparticles produced might be lightly reduced by adding surfactants in preparation process. All results showed that it was useful to prepare high dispersion microparticle by adding surfactants in the preparation process for improving the dissolution.