文献类型：期刊文献

中文题名：可降解自固化类骨磷灰石支架的研究

英文题名：Study on Biodegradable Scaffold of Self-hardening Bone-like Apatite

作者：魏杰[1];刘昌胜[1];洪华[1];袁媛[1];陈芳萍[1]

机构：[1]教育部医用生物材料工程研究中心,华东理工大学生物材料研究所,上海200237

年份：2006

卷号：22

期号：4

起止页码：765

中文期刊名：无机化学学报

外文期刊名：Chinese Journal of Inorganic Chemistry

收录：CSTPCD;;Scopus;北大核心:【北大核心2004】；CSCD:【CSCD2011_2012】；

基金：国家杰出青年基金(No.2042562);上海市重点项目(No.02DZ11013)资助。

语种：中文

中文关键词：骨修复;类骨磷灰石;多孔支架;生物降解性

外文关键词：bone repair; bone-like apatite; porous scaffold; biodegradation

摘要：A novel biodegradable bone repair biomaterial of bone-like carbonated apatite with porous structurewas prepared by using self-hardening calcium phosphate cement. Cell culture, degradation in simulated body liq-uid (SBF) and as a carrier for bone morphogenic protein (BMP) controllable releasing experiments were performedto evaluate the biocompatibility, degradation and BMP carrier properties of the porous scaffold. The results revealthat the degradation property of the carbonated apatite is better than hydroxyapatite, the more the content of CO32-in apatite, the faster the degradation of the materials, the cell could attach, proliferate and differentiate on theporous scaffold, indicating that the bone like apatites not only have excellent biocompatibility but are alsobiodegradable and can be used as carriers for BMP controlling release.
A novel biodegradable bone repair biomaterial of bone-like carbonated apatite with porous structure was prepared by using self-hardening calcium phosphate cement. Cell culture, degradation in simulated body liquid （SBF） and as a carrier for bone morphogenic protein （BMP） controllable releasing experiments were performed to evaluate the biocompatibility, degradation and BMP carrier properties of the porous scaffold. The results reveal that the degradation property of the carbonated apatite is better than hydroxyapatite, the more the content of CO3^2- in apatite, the faster the degradation of the materials, the cell could attach, proliferate and differentiate on the porous scaffold, indicating that the bone like apatites not only have excellent biocompatibility but are also biodegradable and can be used as carriers for BMP controlling release.