文献类型：期刊文献

英文题名：Solubility of Amorphous Clopidogrel Hydrogen Sulfate in Different Pure Solvents

作者：Liu, Yan[1];Zhao, Zhi-Peng[1];Cui, Jingbin[1];Ren, Guobin[1]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Lab Pharmaceut Crystal Engn & Technol, Shanghai 200237, Peoples R China

年份：2015

卷号：60

期号：8

起止页码：2442

外文期刊名：JOURNAL OF CHEMICAL AND ENGINEERING DATA

收录：;EI(收录号：20153301179063);WOS:【SCI-EXPANDED(收录号:WOS:000359683300031)】；

基金：The authors would like to thank the Shanghai Committee of Science and Technology (Grant 12DZ1930702) for financial support.

语种：英文

外文关键词：Acetone - Sulfur compounds

摘要：At the temperature range (273.15 to 308.15) K, the solubility of amorphous clopidogrel hydrogen sulfate (CHS) in pure 1-butanol, 2-butanol, 2-propanol, methyl acetate, ethyl acetate, acetone, and methyl tert-butyl ether (MTBE) were experimentally measured. The order of solubility of amorphous CHS is 1-butanol > acetone > 2-propanol > 2-butanol > methyl acetate > ethyl acetate > MTBE, which is in good agreement with the orders of CHS crystalline forms in the literature. However, the solubility of the amorphous ones is dozens of times higher than that of crystals, respectively. In addition, the modified Apelblat equation was used to correlate the temperature with the mole fraction solubility. Finally, the thermodynamic parameters were calculated by the fitting parameters of the modified Van't Hoff equation.