文献类型：期刊文献

中文题名：钯催化不对称[3+4]环加成构建吲哚并环庚烷

英文题名：Palladium-Catalyzed Asymmetric[3+4]Cycloadditions for the Construction of Cyclohepta[b]indoles

作者：王熠[1];张键[2];刘飏子[2];罗晓燕[1];邓卫平[1,2]

机构：[1]华东理工大学药学院,上海200237;[2]浙江师范大学化学与材料科学学院,浙江金华321004

年份：2023

卷号：43

期号：8

起止页码：2864

中文期刊名：有机化学

外文期刊名：Chinese Journal of Organic Chemistry

收录：CSTPCD;;Scopus;WOS:【SCI-EXPANDED(收录号:WOS:001063823700020)】；北大核心:【北大核心2020】；CSCD:【CSCD2023_2024】；

基金：Project supported by the National Key Research and Development Program of China (No. 2021YFA0804900), the National Natural Science Foundation of China (Nos. 21971062, 22171082) and the Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism.

语种：中文

中文关键词：脱羧;吲哚并环庚烷;不对称;环加成

外文关键词：decarboxylation;cyclohepta[b]indoles;asymmetric;cycloadditions

摘要：报道了一种通过钯催化的脱羧方法,能够以较好的收率、中等至优异的对映选择性,以及良好的非对映选择性高效地合成吲哚并环庚烷类化合物.在该方法中,乙烯基吲哚噁唑酮被钯催化剂活化脱羧形成两性离子中间体,接着被缺电子双烯所捕获发生不对称[3+4]环加成反应.
A Pd-catalyzed decarboxylation strategy for the efficient synthesis of cyclohepta[b]indoles in good yields with good to excellent enantioselectivities and moderate diastereoselectivities is reported.In this procedure,viny indoloxazolidones were activated by Pd catalyst to generate zwitterionic intermediates in situ,which were then trapped by the electro-deficient diene species via the asymmetric[3+4]cycloaddition process.