文献类型：期刊文献

英文题名：Rapamycin and Hyperoside-Co-loaded Macrophage Delivery System Enhanced Pulmonary Fibrosis Therapy by Autophagy Upregulation and Epithelial-to-Mesenchymal Transition Inhibition

作者：Wang, Qi[1];Ning, Yuanmeng[1];Zhang, Jinru[1];Du, Xu[1];Xu, Zihan[1];Hu, Yongcheng[1];Gao, Feng[2];Chen, Yanzuo[1]

机构：[1]East China Univ Sci & Technol, Pharmaceut Engn & Proc Chem Engn Res Ctr, Sch Pharm, Shanghai Key Lab New Drug Design,Minist Educ, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Shanghai Frontiers Sci Ctr Optogenet Tech Cell Met, Sch Pharm, Shanghai 200237, Peoples R China

年份：2024

卷号：16

期号：37

起止页码：48993

外文期刊名：ACS APPLIED MATERIALS & INTERFACES

收录：;EI(收录号：20243617008390);WOS:【SCI-EXPANDED(收录号:WOS:001305377400001)】；

基金：This work was supported by the Natural Science Foundation of Shanghai (Grant No. 22ZR1415500).

语种：英文

外文关键词：pulmonary fibrosis; autophagy; epithelial-to-mesenchymaltransition; macrophage drug delivery system; extracellulartraps

摘要：Pulmonary fibrosis is a lethal interstitial lung disease, for which current treatments are inadequate in halting its progression. A significant factor contributing to the development of fibrosis is insufficient autophagy, which leads to increased fibroblast proliferation and collagen deposition. However, treatments aimed at upregulating autophagy often cause further lung pathology due to the disruption of epithelial cell balance. In response, we have developed a novel macrophage delivery system loaded with an epithelial-to-mesenchymal transition inhibitor, hyperoside (HYP), and an autophagy inducer, rapamycin (RAP). This system targets the fibrotic areas of the lung through chemotaxis, releases liposomes via macrophage extracellular traps, and effectively inhibits fibroblast proliferation while restoring the alveolar structure through the combined effects of RAP and HYP, ultimately reducing lung pathology without causing systemic toxicity. Our findings not only highlight a promising method to enhance autophagy-based treatments for pulmonary fibrosis but also demonstrate the potential of macrophages as effective nanocarriers for drug delivery.