详细信息
灰黄霉素在含共溶剂丙酮的超临界CO_2中溶解度的测定和关联
Measurement and correlation of solubility of griseofulvinin supercritical CO_2 with acetone as cosolvent
文献类型:期刊文献
中文题名:灰黄霉素在含共溶剂丙酮的超临界CO_2中溶解度的测定和关联
英文题名:Measurement and correlation of solubility of griseofulvinin supercritical CO_2 with acetone as cosolvent
作者:胡国勤[1];蔡建国[1];陈鸿雁[1];邓修[1]
机构:[1]华东理工大学化学工程研究所
年份:2004
卷号:35
期号:2
起止页码:81
中文期刊名:中国医药工业杂志
外文期刊名:Chinese Journal of Pharmaceuticals
收录:CSTPCD;;北大核心:【北大核心2000】;CSCD:【CSCD2011_2012】;
语种:中文
中文关键词:灰黄霉素;超临界流体;共溶剂;溶解度;关联;测定
外文关键词:griseofulvin; supercritical fluid; cosolvent; solubility; correlation
摘要:动态法测定了灰黄霉素在不同的操作温度、压力以及共溶剂丙酮浓度下在超临界CO2中的溶解度。用修正的PR状态方程关联了三元系统的溶解度模型,效果较好。
The solubility of griseofulvin in supercritical CO2 with cosolvent acetone at different temperature,pressure and concentration was measured in this study. The modified PR-EOS was successfully used to correlate the solubi-lity of griseofulvin in this tertiary system.
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