文献类型：期刊文献

英文题名：Sterically stabilized spongosomes for multidrug delivery of anticancer nanomedicines

作者：Chen, Yiyin[1];Angelova, Angelina[2];Angelov, Borislav[3];Drechsler, Markus[4];Garamus, Vasil M.[5];Willumeit-Roemer, Regine[5];Zou, Aihua[1]

机构：[1]E China Univ Sci & Technol, Shanghai 200237, Peoples R China;[2]Univ Paris 11, LabEx LERMIT, Inst Galien Paris Sud, CNRS,UMR8612, F-92296 Chatenay Malabry, France;[3]Acad Sci Czech Republ, Inst Macromol Chem, CR-16206 Prague, Czech Republic;[4]Univ Bayreuth, Bayreuth Inst Macromol Res BIMF, Lab Soft Matter Electron Microscopy, D-95440 Bayreuth, Germany;[5]Helmholtz Zentrum Geesthacht, Ctr Mat & Coastal Res, D-21502 Geesthacht, Germany

年份：2015

卷号：3

期号：39

起止页码：7734

外文期刊名：JOURNAL OF MATERIALS CHEMISTRY B

收录：;EI(收录号：20154001344291);WOS:【SCI-EXPANDED(收录号:WOS:000362350600011)】；

基金：A.Z. and Y.C. thank the Shanghai Natural Science Foundation (K100-2-15017), the National Natural Science Foundation of China (No. 21573070), Fundamental Research Funds for the Central Universities and Alexander von Humboldt Foundation for financial support. B.A. thanks the Czech Science Foundation (Grant No. GACR 15-10527J) and M.D. thanks BIMF (Bayreuth Institute of Macromolecular Research) and BZKG (Bayreuth Center for Colloids and Interfaces) for financial support.

语种：英文

外文关键词：Controlled drug delivery - Cell culture - X ray scattering - Biological organs - Encapsulation - Flavonoids - High resolution transmission electron microscopy - Targeted drug delivery - Self assembly - Chemical stability - Crystalline materials

摘要：Multidrug delivery devices are designed to take advantage of the synergistic effects of anticancer agents in combination therapies. Here we report novel liquid crystalline self-assembled nanocarriers enhancing the activity of the phytochemical anticancer agent baicalin (BAI) in combination with Brucea javanica oil (BJO), which ensures safe formulations for clinical applications. Small-angle X-ray scattering (SAXS) and cryogenic transmission electron microscopy (cryo-TEM) evidenced the multicompartment, sponge-type nano-organization of the blank and multidrug-loaded liquid crystalline carriers. Physico-chemical stability of the sponge nanoparticles was achieved through PEGylation of the lipid membranes, which make up the drug nanocarriers. The proposed green nanotechnology for nanocarrier preparation by supramolecular self-assembly provided a multidrug encapsulation efficiency as high as 75%. The apoptosis study with the human lung carcinoma cell line A549 demonstrated improved efficacy of the multidrug delivery nanocarriers in comparison to the single-drug reservoirs. The obtained results evidenced the synergistic anticancer apoptotic effects of the multidrug-loaded nanosponge carriers and suggested the opportunity for in vivo translation towards the treatment of lung, gastrointestinal, and ovarian cancers.