文献类型：期刊文献

英文题名：Stress-responses of microbial population and activity in activated sludge under long-term ciprofloxacin exposure

作者：Chen, Ya[1];Wang, Zhiping[1];Liu, Lili[2];Zhao, Hanbin[2];Wu, Pin[3]

机构：[1]Shanghai Jiao Tong Univ, Sch Environm Sci & Engn, Shanghai 200240, Peoples R China;[2]East China Univ Sci & Technol, State Environm Protect Key Lab Environm Risk Asse, Shanghai 200237, Peoples R China;[3]Shanghai Jiao Tong Univ, China UK Low Carbon Coll, Shanghai 200240, Peoples R China

年份：2021

卷号：281

外文期刊名：JOURNAL OF ENVIRONMENTAL MANAGEMENT

收录：;EI(收录号：20233314559120);WOS:【SCI-EXPANDED(收录号:WOS:000618048000007)】；

基金：This work was sponsored by Major Science & Technology Program for Water Pollution Control and Treatment of China (2017ZX07206004).

语种：英文

外文关键词：Antibiotic; Ciprofloxacin; Activated sludge; Microbial community; Metabolism

摘要：In this study, the effects of ciprofloxacin on activated sludge were evaluated based on the microbial community and metabolic characteristics. The results indicated that the metabolism of chemical oxygen demand (COD) and nitrogen were inhibited with ciprofloxacin at mg/L level compared to the control experiment, and the concentration of ciprofloxacin was slightly decreased. High-throughput sequencing (HTS) results showed that ciprofloxacin greatly shaped the microbial communities in activated sludge, especially for the Nitrospirae phylum and Nitrospira genus. High concentrations of ciprofloxacin stimulated the enrichment of Zoogloea, thus reducing the stability of the activated sludge. Moreover, quinolone resistance proteins in Aeromonas were enriched, which demonstrates their competitive advantage in these enrichment incubations. Finally, the functional profiles were predicted through Tax4Fun, which revealed the adaption to microbes in activated sludge to the ciprofloxacin selective pressure. This work demonstrates the influence of ciprofloxacin on the activated sludge process, and can provide a useful reference for the assessment of the ecological security of ciprofloxacin.