文献类型：期刊文献

英文题名：Towards efficient terpenoid biosynthesis: manipulating IPP and DMAPP supply

作者：Wang, Qin[1,2];Quan, Shu[3];Xiao, Han[1,2]

机构：[1]Shanghai Jiao Tong Univ, State Key Lab Microbial Metab, Joint Int Res Lab Metab & Dev Sci, 800 Dong Chuan Rd, Shanghai 200240, Peoples R China;[2]Shanghai Jiao Tong Univ, Lab Mol Biochem Engn, Sch Life Sci & Biotechnol, 800 Dong Chuan Rd, Shanghai 200240, Peoples R China;[3]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, SCICB, Shanghai 200237, Peoples R China

年份：2019

卷号：6

期号：1

外文期刊名：BIORESOURCES AND BIOPROCESSING

收录：;EI(收录号：20224513085263);WOS:【SCI-EXPANDED(收录号:WOS:000461500200002)】；

基金：This work was supported by the National Natural Science Foundation of China (No. 31600071), Municipal Natural Science Foundation of Shanghai (Nos. 17ZR1448900, 18ZR1420300), and Open Funding Project of the State Key Laboratory of Bioreactor Engineering.

语种：英文

外文关键词：Terpenoid; Mevalonate pathway; 2-C-Methyl-D-erythritol 4-phosphate (MEP); Isopentenyl diphosphate (IPP); Dimethylallyl diphosphate (DMAPP); Biosynthesis

摘要：Terpenoids are a group of largest natural products with important biological functions, and their efficient biosynthesis is of particular importance to both academia and industry. As the building blocks for terpenoid biosynthesis, a suitable supply of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) is extremely crucial for efficient terpenoid biosynthesis. With this focus, we first introduce biosynthetic pathways of IPP and DMAPP, and then summarize the current strategies adopted for manipulating IPP and DMAPP supply. At last, how to further manage IPP and DMAPP supply to improve terpenoid biosynthesis is also proposed.