文献类型：期刊文献

英文题名：Copper functionalized poly (acrylic acid-co-itaconic acid) nanohydrogel: Its antibacterial properties on oral pathogens and biocompatibility

作者：Zhan, Lingnv[1,2,3,4,5];Qian, Qiuping[6];Zhang, Yao[7,8,12];Qi, Zhengnan[9,10,11];Zhang, Ling[1,2,3,4,5];Fang, Haiping[12];Tang, Zisheng[1,2,3,4,5];Zhou, Yunlong[6]

机构：[1]Shanghai Jiao Tong Univ, Dept Endodont, Shanghai Peoples Hosp 9, Sch Med, Shanghai 200011, Peoples R China;[2]Shanghai Jiao Tong Univ, Coll Stomatol, Shanghai 200011, Peoples R China;[3]Natl Ctr Stomatol, Shanghai 200011, Peoples R China;[4]Natl Clin Res Ctr Oral Dis, Shanghai 200011, Peoples R China;[5]Shanghai Key Lab Stomatol, Shanghai 200011, Peoples R China;[6]Univ Chinese Acad Sci, Engn Res Ctr Clin Funct Mat & Diag & Treatment De, Wenzhou Inst, Wenzhou 325000, Zhejiang, Peoples R China;[7]Univ Chinese Acad Sci, Wenzhou Inst, Wenzhou 325000, Zhejiang, Peoples R China;[8]Zhejiang Lab Regenerat Med Vis & Brain Hlth, Oujiang Lab, Wenzhou 325001, Zhejiang, Peoples R China;[9]Fudan Univ, Shanghai Stomatol Hosp, Dept Endodont, Shanghai 200001, Peoples R China;[10]Fudan Univ, Sch Stomatol, Shanghai 200001, Peoples R China;[11]Fudan Univ, Shanghai Key Lab Craniomaxillofacial Dev & Dis, Shanghai 200001, Peoples R China;[12]East China Univ Sci & Technol, Dept Phys, Shanghai 200237, Peoples R China

年份：2022

卷号：218

外文期刊名：COLLOIDS AND SURFACES B-BIOINTERFACES

收录：;EI(收录号：20223312563004);WOS:【SCI-EXPANDED(收录号:WOS:000888203700003)】；

基金：This work was funded by the National Natural Science Foundation of China (81870749, 82071105, 21934007, 11974366, 51901130), the Cross-disciplinary Research Fund of Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine (JYJC202006), the project of the Science and Technology Department of Sichuan Province (2020YFSY0019), the Fundamental Research Funds for the Central Universities, China, and grants from Wenzhou Institute, University of Chinese Academy of Sciences (WIUCASQD2019001, WIU-CASQD2021014, WIUCASQD2021039).

语种：英文

外文关键词：Poly (acrylic acid-co-itaconic acid); Copper functionalized hydrogel; Antibacterial activity; Oral pathogens; Biocompatibility

摘要：Although extensive efforts have been made to explore effective antibiotics, the development of antibiotics lags far behind the emergence of drug-resistant bacteria. Antimicrobial materials as an alternative strategy provide effective functions in aiding in relieving the dose of antibiotics. Herein, we report a novel antibacterial agent with high antibacterial effectivity and low toxicity, which is simply composed of a trace amount of Cu2+ ion and nanoscale biocompatible polymer poly (acrylic acid-co-itaconic acid) (PAI-Cu). The polymer shows greatly enhanced antibacterial activity against various Gram-positive and Gram-negative pathogens compared with equal concentrations of copper ion solution, yet shows nearly no toxicity towards human cells. The antibacterial performance and mechanism of copper ionized polymer hydrogel are evaluated in terms of multiple methods, towards various oral bacteria including Streptococcus mutans, Enterococcus faecalis, Lactobacillus acidophitus, Actinomycetes viscosus, Porphyromonas gingivalis, Fusobacterium nucleatum, Aggregatibacter actinomycetemcomitans, and Prevotella intermedia. Bacterial cell membrane and wall damage caused by PAI-Cu nanohydrogel should be regarded as an important antibacterial mechanism. Moreover, PAI-Cu nanohydrogel, as the role of catalytic active center, can activate the surrounding oxygen, and generate hydroxyl radical (center dot OH), which can destroy the proliferation ability of microbial cells. We suggest that PAI-Cu nanohydrogel is a promising antibacterial agent against dental pathogens and beyond.