文献类型：期刊文献

英文题名：Inactivation of β-catenin results in the reduction of postnatal body weight gain

作者：Wang, Hong-Tao[1];Zeng, Lin[1];Zhang, Xin[1];Li, Kui[1];Zu, Yong[1];Liu, Ji-wei[1];Liu, Yong-jie[1];Zhu, Zhi-chuan[1];Xiong, Zhi-Qi[2];Zheng, Jing[1];Hu, Ze-Lan[1]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China;[2]Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai 200031, Peoples R China

年份：2014

卷号：100

起止页码：55

外文期刊名：BRAIN RESEARCH BULLETIN

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000331480000008)】；

基金：The authors thank Dr. Bin Lu and Dr. Ting-jia Lu for assistance in technical help. This study was partially supported by the Shanghai Committee of Science and Technology (grant No. 11DZ2260600) and Shanghai Postdoctoral Science Foundation grant to Ze-Lan Hu.

语种：英文

外文关键词：Arcuate nucleus of hypothalamus; beta-Catenin; NPY; POMC; Body weight

摘要：Arcuate nucleus of hypothalamus (ARH) is the core component in the regulation circuits of food intake and energy homeostasis. ARH projections to other parts of the hypothalamus and to extrahypothalamic areas are established in the postnatal two weeks, which is a pivotal stage for individual development. beta-Catenin, a cell adhesion protein and also the mediator of canonical Wilt signaling pathway, plays an important role in embryonic development and adult homeostasis. However, whether beta-catenin plays any roles in the development of hypothalamus is not clear. Here, we report that perinatal conditional knockout of beta-catenin by CamKII alpha-Cre in forebrain reduces body weight gain from P8 and dramatically shortens life span. Quantitative PCR and in situ hybridization results showed the expression of NPY mRNA in the ARH of beta-catenin CKO mice at P15 is obviously increased compared with that of littermate controls, whereas the expression of POMC mRNA is significantly decreased, which suggested the reduction of postnatal body weight gain might be due to the deficiency of food intake. Together, beta-catenin might play an important role in the regulation of food intake and postnatal body weight gain probably through affecting the development of ARH circuits. (C) 2013 Elsevier Inc. All rights reserved.