文献类型：期刊文献

英文题名：Dually responsive mesoporous silica nanoparticles regulated by upper critical solution temperature polymers for intracellular drug delivery

作者：Hei, Mingyang[1,2];Wang, Jun;Wang, Kelly[3];Zhu, Weiping[2];Ma, Peter X.[1,3,4]

机构：[1]Univ Michigan, Dept Biol & Mat Sci, Ann Arbor, MI 48109 USA;[2]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, State Key Lab Bioreactor Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China;[3]Univ Michigan, Macromol Sci & Engn Ctr, Ann Arbor, MI 48109 USA;[4]Univ Michigan, Dept Biomed Engn, Dept Mat Sci & Engn, Ann Arbor, MI 48109 USA

年份：2017

卷号：5

期号：48

起止页码：9497

外文期刊名：JOURNAL OF MATERIALS CHEMISTRY B

收录：;EI(收录号：20175104561648);WOS:【SCI-EXPANDED(收录号:WOS:000418072200006)】；

基金：We thank the NIH of USA (R01HL136231, R01HL114038, R01DE022327, and R42TR001711) and NNSF of China (Grants 21476077) for financial support. This work was carried out in the Polymeric Biomaterials and Tissue Engineering Laboratory at the University of Michigan, where M. Hei was a joint PhD student and partially supported by a fellowship from the Chinese Scholarship Council.

语种：英文

外文关键词：Cancer cells - Covalent bonds - Silica nanoparticles - Sulfur compounds - Targeted drug delivery - Controlled drug delivery

摘要：We synthesized a new type of upper critical solution temperature (UCST) thermally responsive polymer (TRP) with varying responsive temperatures (cloud points). We then grafted one of the TRPs with a cloud point of 42 degrees C onto the surface of mesoporous silica nano-particles (MSNs) using disulfide bonds to achieve a novel, dual responsive release system. With this system, the cargo release profiles are responsive to both temperature and reducing agents. When loaded with doxorubicin hydrochloride (DOX), the system could deliver DOX into breast cancer cells (SK-BR-3) in a controlled fashion and present high toxicity.