文献类型：期刊文献

英文题名：Toxicity of a molluscicide candidate PPU07 against Oncomelania hupensis (Gredler, 1881) and local fish in field evaluation

作者：Chen, Zhuo[1];Wang, Weisi[2];Yao, Junmin[2];Li, Shizhu[2];Zhang, Xia[3];Hu, Hehua[3];Liu, Xiong[3];Luo, Binrong[4];Liu, Yuhua[4];Xu, Huiyong[5];Duan, Liping[2,5,6]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China;[2]Chinese Minist Hlth, WHO Collaborating Ctr Malaria Schistosomiasis & F, Chinese Ctr Dis Control & Prevent, Key Lab Parasitol & Vector Biol,Natl Inst Parasit, Shanghai 200025, Peoples R China;[3]Jianglin Inst Schistosomiasis Control, Jianglin 434100, Hubei, Peoples R China;[4]Dali Inst Schistosomiasis Control, Dali 671000, Yunnan, Peoples R China;[5]Jiangsu Acad Agr Sci, Nanjing 210014, Jiangsu, Peoples R China;[6]Chinese Acad Sci, Inst Microbiol, Beijing 100101, Peoples R China

年份：2019

卷号：222

起止页码：56

外文期刊名：CHEMOSPHERE

收录：;EI(收录号：20190606469001);WOS:【SCI-EXPANDED(收录号:WOS:000462109200008)】；

基金：This work was supported by the National Key R&D Program of China (2017YFC1200600).

语种：英文

外文关键词：Molluscicide; Oncomelania hupensis; Schistosoma japonicum; Fish toxicity; PPU07

摘要：Schistosomiasis japonica caused by Schistosoma japonicum infection is recognized as a considerable economic and public health concern in Asia. Oncomelania hupensis is the sole intermediate host of S. japonicum. The only molluscicide recommended by World Health Organization (WHO) since 1960s is relative toxic to other aquatic species. In this article, we evaluated the novel molluscicide PPU07 in field trials on their efficiency against O. hupensis and toxicity for local fish. 25% PPU07 sulfate WP exhibited similar molluscicidal effect at 2.0 g/m(2) and 2.0 g/m(3) in the spraying and immersion trials with the WHO recommended molluscicide niclosamide (1 g/m(2) and 1 g/m(3)). The mortality rates reached 95% and 96%, respectively. Moreover, little toxicity was observed for local fish and other aquatic organisms at the effective molluscicidal concentrations. In all, 25% PPU07 sulfate WP is a promising molluscicide for snail control, particularly in semi-commercial or commercial aquaculture ponds. (C) 2019 Elsevier Ltd. All rights reserved.