文献类型：期刊文献

英文题名：D-A-D fluorogenic probe for the rapid imaging of amyloid β plaques in vivo

作者：Yang, Hao-Yu[1,2,4];Zhang, Jing-Jing[4];Zang, Yi[3];Zhang, Hai-Yan[4];Li, Jia[3];Chen, Guo-Rong[1,2];He, Xiao-Peng[1,2]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Chem & Mol Engn, Inst Fine Chem, Shanghai 200237, Peoples R China;[3]Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Natl Ctr Drug Screening, 189 Guo Shoujing Rd, Shanghai 201203, Peoples R China;[4]Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China

年份：2017

卷号：136

起止页码：224

外文期刊名：DYES AND PIGMENTS

收录：;EI(收录号：20163602764403);WOS:【SCI-EXPANDED(收录号:WOS:000387837200028)】；

基金：This research is supported by the 973 project (2013CB733700), the Natural Science Foundation of China (21572058, 21576088, 81302820 and 81522045), the National Science and Technology Major Projects (2014ZX09507-002), the Shanghai Science and Technology Development Funds (14YF1413300) and the Shanghai Rising-Star Program (16QA1401400).

语种：英文

外文关键词：Amyloid beta; Probe; Fluorescence; In vivo imaging; Alzheimer's disease

摘要：The effective imaging of amyloid beta (A beta) in vivo is important for the diagnosis of All-related diseases such as the Alzheimer's disease (AD). Here we report a donor-acceptor-donor (D-A-D) type fluorogenic probe for the rapid imaging of amyloid beta (A beta) senile plaques in a transgenic mouse brain. The probe that features a dicyanomethylene-4H-pyran (DCM) core shows a concentration-dependent fluorescence enhancement with A beta 42 and A beta 40, which are the main components of A beta fibrils formed in the brain of AD patients. The D-A-D probe can also be used to rapidly sense A beta peptide monomer, oligomer and fibril in an aqueous solution and image the morphologically diverse A beta species by confocal microscopy. In particular, we demonstrate that the probe can be used to rapidly stain A beta senile plaques in the brain of transgenic mice by intravenous injection. (C) 2016 Elsevier Ltd. All rights reserved.