文献类型：期刊文献

英文题名：Interplay of Direct Stereocontrol and Dynamic Kinetic Resolution in a Bifunctional Amine Thiourea Catalyzed Highly Enantioselective Cascade Michael-Michael Reaction

作者：Yu, Chenguang[1,2];Zhang, Yinan[1];Song, Aiguo[1];Ji, Yafei[1,3];Wang, Wei[1,3,4]

机构：[1]Univ New Mexico, Dept Chem & Chem Biol, Albuquerque, NM 87131 USA;[2]Beijing Univ Chem Technol, State Key Lab Chem Resources Engn, Beijing 100029, Peoples R China;[3]E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China;[4]Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China

年份：2011

卷号：17

期号：3

起止页码：770

外文期刊名：CHEMISTRY-A EUROPEAN JOURNAL

收录：;EI(收录号：20110313599502);WOS:【SCI-EXPANDED(收录号:WOS:000287259700006)，CCR-EXPANDED(收录号:WOS:000287259700006)】；

基金：Financial support provided by the National Science Foundation (CHE-0704015, W.W.), the China "111" project (Grant B07023, W.W.) and the Chinese Scholarship Council (C.-G.Y.) is gratefully acknowledged.

语种：英文

外文关键词：amine thioureas; cascade catalysis; dynamic kinetic resolution; organocatalysis; tetrahydrothiophenes

摘要：Control is better: A novel chiral amine thiourea catalyzed, highly enantioselective Michael-Michael cascade process serves as a "one-pot" approach to synthetically and biologically significant chiral tetrahydrothiophenes (see scheme). Notably, an unprecedented cooperative direct stereocontrol and dynamic kinetic resolution by the bifunctional catalyst is identified that governs the highly enantioselective cascade process. Copyright ? 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.