文献类型：期刊文献

中文题名：挤出滚圆法制备药用微丸Ⅱ.制备工艺

英文题名：SPHERICAL PELLETS PREPARED BY EXTRUSION SPHERONIZATION Ⅱ. PREPARATION TECHNOLOGY

作者：包泳初[1,2];陈庆华[1,2];刘伟伦[1,2];潘家祯[1,2];孙晓明[1,2]

机构：[1]上海医药工业研究院;[2]华东理工大学化工机械研究所

年份：1999

卷号：30

期号：1

起止页码：18

中文期刊名：中国医药工业杂志

外文期刊名：Chinese Journal of Pharmaceuticals

收录：CSTPCD;;北大核心:【北大核心1996】；CSCD:【CSCD2011_2012】；

语种：中文

中文关键词：挤出-滚圆法;微丸;微晶纤维素

外文关键词：extrusion spheronization,pellets,microcrystalline cellulose

摘要：采用新型的挤出－滚圆装备，以微晶纤维素为辅料，水为粘合剂制备非载药微丸。采用正交试验考察水分、挤出转速、滚圆转速、滚圆时间等因素对（空白）微丸质量影响，还比较了国产微晶纤维素与两种进口品成丸的优缺点。
Pellets using microcrystalline cellulose (MCC) as matrix and water as adherent were prepared by a new style extrusion spheronization equipment.By means of or thogonal design, the influencing factors were water added, extrusion speed, spheronization speed and spheronization time.The effects of domestic and imported MCC (Avicel PH101 and Vivacel 101) were compared.