文献类型：期刊文献

英文题名：Syntheses and insecticidal activities of novel 2,5-disubstituted 1,3,4-oxadiazoles

作者：Zheng, XM; Li, Z; Wang, YL; Chen, WD; Huang, QC; Liu, CX; Song, GH

机构：[1]E China Univ Sci & Technol, Inst Pesticides & Pharmaceut, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China;[2]Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116012, Peoples R China

年份：2003

卷号：123

期号：2

起止页码：163

外文期刊名：JOURNAL OF FLUORINE CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000186001600002)】；

语种：英文

外文关键词：fluoroaryl; 1,3,4-oxadiazoles; insecticidal activity; armywonn

摘要：Nine novel symmetrical and asymmetrical 2,5-disubstituted 1,3,4-oxadiazoles have been synthesized by a facile and mild method with high yield. Meantime, it was found that the fluorine was easy substituted by hydrazine in polyhalogen-substituted aroyl hydrazine. The preliminary bioassay tests show that two of the compounds (D5 and D6) exhibited a significant insecticidal activity (LC50 = 116.02 and 70.93 mg l(-1)) on armyworm, Leucania separata Walker. Using the Drug Discovery Workbench (DDW) (Cerius(2)), structure-activities relationship was studied. (C) 2003 Elsevier B.V. All rights reserved.