文献类型：期刊文献

英文题名：Inflammatory Oriented Nanospheres-Reconstructed Extracellular Matrix in Ischemic Stroke

作者：Gao, Zehua[1,2];Wang, Xuanlin[1,2];Zhang, Wenchao[1,2];Wang, Jing[1,2];Liu, Changsheng[2,3]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Minist Educ, Engn Res Ctr Biomed Mat, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China

年份：2025

卷号：19

期号：24

起止页码：22065

外文期刊名：ACS NANO

收录：;EI(收录号：20252418598935);WOS:【SCI-EXPANDED(收录号:WOS:001507355800001)】；

基金：This research was supported by the Key Program of the National Natural Science Foundation of China (No. 32230059), the Basic Science Center Program of National Natural Science Foundation of China (No. T2288102), the National Natural Science Foundation of China (No. 32471406), and the Foundation of Frontiers Science Center for Materiobiology and Dynamic Chemistry (JKVD1211002).

语种：英文

外文关键词：nanospheres; stroke; inflammation; extracellular matrix; neurovascular units

摘要：The prevention and treatment of postoperative complications of ischemic stroke remain significant challenges. These complications primarily result from the destruction of the extracellular matrix (ECM) and neurovascular units. In the subacute phase, chronic inflammation further aggravates brain tissue damage. To address these challenges, we propose a strategy to prevent secondary brain injury and complications by modulating immunity and ECM remodeling. To specifically target the inflammatory microenvironment within the ischemic core, we designed sulfonated chitosan liposome microspheres embedded with neutrophil membranes (MLS). These MLS inhibitors inhibited glial scar formation and promoted collagen IV expression. By effectively regulating ECM reconstruction, we aimed to create a favorable microenvironment for the remodeling of neurovascular units and neurofilaments, thereby reducing the number of secondary injuries. Additionally, the high expression of alpha 5 beta 1 in brain endothelial cells (bEnd.3) facilitated the formation of a mature vascular network. This finding represents a therapy for preventing and treating postoperative complications of ischemic stroke. Through modulation of immunity and ECM remodeling, this approach provides a targeted and effective solution to minimize secondary injuries and improve overall rehabilitation outcomes.