文献类型：期刊文献

英文题名：N-Difluoromethylthiophthalimide Reagents for Modular Synthesis of Diversified α-Difluoromethylthiolated Ketones

作者：Liang, Junqing[1,2];Fu, Wen[1,2];Dong, Lefeng[1,2];Zhou, Cong[1,2];Yuan, Qinglong[1,2];Chang, Wenning[1,2];Yang, Wu-Lin[1,2];Xu, Xiaoyong[1,2];Shao, Xusheng[1,2];Li, Zhong[1,2]

机构：[1]East China Univ Sci & Technol, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China

年份：2023

卷号：25

期号：26

起止页码：4797

外文期刊名：ORGANIC LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001013658800001)，CCR-EXPANDED(收录号:WOS:001013658800001)】；

基金：This work was financially supported by the Innovation Program of Shanghai Municipal Education Commission (201701070002E00037). This work was also supported by the National Key Research Program of China (2017YFD0200505) and the Fundamental Research Funds for the Central Universities.

语种：英文

摘要：The compounds featuring & alpha;-difluorothiomethylatedketone skeletonderivatives are of particular interest in pharmaceuticals and agrochemicals.Herein, we designed novel electrophilic N-difluoromethylthiophthalimidereagents that can be easily prepared with commercially available andeconomical chemicals. These reagents could smoothly react with variousnucleophiles, such as Grignard reagents, boronic acids, & beta;-ketoesters, and anilines, which affords structurally diverse & alpha;-difluoromethylthiolatedketones in good to excellent yields. The formal synthesis of activeantifungal compounds positively confirmed the practicability of thesereagents.