文献类型：期刊文献

中文题名：Synthesis and Acid-Catalyzed Cyclization of 2-Alkenylstilbenes： a New Approach to the Substituted Indenes

英文题名：Synthesis and Acid-Catalyzed Cyclization of 2-Alkenylstilbenes： a New Approach to the Substituted Indenes

作者：Wei Ding Xiaoxin Shi Xia Lu[1]

机构：[1]Department of Pharmaceutical Engineering, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China

年份：2015

卷号：33

期号：11

起止页码：1276

中文期刊名：Chinese Journal of Chemistry

外文期刊名：中国化学（英文版）

收录：CSTPCD;;Scopus;CSCD:【CSCD2015_2016】；

基金：We are grateful to the National Natural Science Foundation of China （No. 20972048） for the financial support of this work

语种：英文

中文关键词：isochroman;stilbene;indene;cyclization;ring-opening;synthetic methodology

外文关键词：isochroman, stilbene, indene, cyclization, ring-opening, synthetic methodology

摘要：A base-catalyzed ring-opening of 1-benzylisochromans 1 firstly produced 2-alkenylstilbenes 2, which then underwent a mild acid-catalyzed intramolecular cyclization to furnish 1,2-disubstituted indenes 3 in high yields. Subsequently, a base-catalyzed isomerization of the 1,2-disubstituted indenes 3 afforded the more stable 2,3-disubstituted indenes 4 in almost quantitative yields.
A base-catalyzed ring-opening of 1-benzylisochromans 1 firstly produced 2-alkenylstilbenes 2, which then underwent a mild acid-catalyzed intramolecular cyclization to furnish 1,2-disubstituted indenes 3 in high yields. Subsequently, a base-catalyzed isomerization of the 1,2-disubstituted indenes 3 afforded the more stable 2,3-disubstituted indenes 4 in almost quantitative yields.