文献类型：期刊文献

英文题名：Axially Chiral N,N-Ligand-Promoted Pd-Catalyzed Enantioselective Allylic Amination and Alkylation

作者：Liu, Miaomiao[1];Zhang, Xiaotao[1];Bao, Rongrong[1];Xiao, Fangtao[1];Cen, Shouyi[1];Zhang, Zhipeng[2,3]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Chem & Mol Engn, Frontiers Sci Ctr Materiobiol & Dynam Chem, Key Lab Adv Mat,Feringa Nobel Prize Scientist Joi, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Sch Chem & Mol Engn, Frontiers Sci Ctr Materiobiol & Dynam Chem, Joint Int Res Lab Precis Chem & Mol Engn,Feringa, Shanghai 200237, Peoples R China

年份：2023

卷号：25

期号：32

起止页码：5946

外文期刊名：ORGANIC LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001049545700001)，CCR-EXPANDED(收录号:WOS:001044959900001)】；

基金：The authors thank the Research Center of Analysis and Test, East China University of Science and Technology, for the help on the characterization. The authors acknowledge the National Natural Science Foundation of China (21702059), the Fundamental Research Funds for the Central Universities (222201717003, 222201814014, JKJ01221640, JKVJ1221010, and JKVJ1231010), the Shanghai Pujiang Program (18PJ1402200), the Shanghai Municipal Science and Technology Major Project (2018SHZDZX03), the Program of Introducing Talents of Discipline to Universities (B16017), and the "Thousand Plan" Youth Program for financial support.

语种：英文

摘要：An axially chiral N,N-ligand developed from a [1,1 & PRIME;-binaphthalene]-2,2 & PRIME;-diol(BINOL)-based skeleton and phenanthroline is found to be capable ofpromoting Pd-catalyzed asymmetric allylic amination and alkylationof allyl acetates. The reaction is compatible with cyclic and acyclicsecondary amines, primary aliphatic amines, malononitrile, and dialkylmalonates, affording the corresponding chiral products in up to 99%yield and with up to >99% enantiomeric excess.