文献类型：期刊文献

英文题名：Preparation of Electrospun Gelatin Mat with Incorporated Zinc Oxide/Graphene Oxide and Its Antibacterial Activity

作者：Li, Honghai[1,2];Chen, Yu[1,3];Lu, Weipeng[1];Xu, Yisheng[2];Guo, Yanchuan[1,3];Yang, Geng[1,3]

机构：[1]Chinese Acad Sci, Tech Inst Phys & Chem, Key Lab Photochem Convers & Optoelect Mat, Beijing 100190, Peoples R China;[2]East China Univ Sci & Technol, Sch Chem Engn, Shanghai 200237, Peoples R China;[3]Univ Chinese Acad Sci, Sch Future Technol, Beijing 100049, Peoples R China

年份：2020

卷号：25

期号：5

外文期刊名：MOLECULES

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000529219900026)】；

基金：This work was supported by the State Natural Sciences Fund, China (Project No. 21506236, 51372276), Research and Application of Gelatin Green Manufacturing 2.0 Technology by Enzymatic method (KFJ-STS-ZDTP-016) and Hangzhou Research Institute of Technical Institute of Physics and Chemistry, CAS Fund (Project No. 2016050201, 2016050202).

语种：英文

外文关键词：gelatin fibers; electrospinning; ZnO; GO; antibacterial activity; wound dressing

摘要：Current wound dressings have poor antimicrobial activities and are difficult to degrade. Therefore, biodegradable and antibacterial dressings are urgently needed. In this article, we used the hydrothermal method and side-by-side electrospinning technology to prepare a gelatin mat with incorporated zinc oxide/graphene oxide (ZnO/GO) nanocomposites. The resultant fibers were characterized by field emission environment scanning electron microscopy (FESEM), energy-dispersive X-ray spectroscopy (EDX), X-ray diffractometry (XRD) and Fourier transform infrared spectroscopy (FTIR). Results indicated that the gelatin fibers had good morphology, and ZnO/GO nanocomposites were uniformly dispersed on the fibers. The loss of Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) viability were observed to more than 90% with the incorporation of ZnO/GO. The degradation process showed that the composite fibers completely degraded within 7 days and had good controllable degradation characteristics. This study demonstrated the potential applicability of ZnO/GO-gelatin mats with excellent antibacterial properties as wound dressing material.